Visualization of macromolecular structures.

European Molecular Biology Laboratory, Heidelberg, Germany.
Nature Methods (Impact Factor: 23.57). 03/2010; 7(3 Suppl):S42-55. DOI: 10.1038/nmeth.1427
Source: PubMed

ABSTRACT Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

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