Chlamydophila psittaci infections in turkeys: overview of economic and zoonotic importance and vaccine development.
ABSTRACT We provide evidence on the multifactorial infectious etiology of respiratory disease in turkeys. Although Chlamydophila psittaci is difficult to diagnose, this entity should not be neglected in veterinary diagnostic laboratories. The present results suggest a pathogenic interplay between chlamydophila, avian metapneumovirus and Ornithobacterium rhinotracheale. Additionally, we demonstrate zoonotic transmission from turkeys to humans. Psittacosis due to contact with poultry probably occurs more often than is thought and the infection can be asymptomatic or symptomatic. There is no commercial C. psittaci vaccine available and currently the best option is an experimental major outer membrane protein-based DNA vaccine.
- SourceAvailable from: Si Yang Huang[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Chlamydiaceae is a family of obligate intracellular pathogens with a worldwide distribution in many animal species, including humans. No information exists on the prevalence of Chlamydia felis infections in cats and dogs in Lanzhou, the geographical center of China. The aim of this study was to carry out a census of cats and dogs in Lanzhou and document the seroprevalence of C. felis exposure in these companion animals. RESULTS: In this study, blood samples were collected from 485 animals (221 cats and 264 pet dogs) in Lanzhou between November 2010 and July 2011 to identify antibodies against C. felis. Thirteen of 221 (5.9%) cats and 32 of 264 (12.1%) pet dogs were positive for C. felis infection using indirect hemagglutination at a cutoff of 1:16. The seroprevalence in household and stray cats was 3.9% and 14.3%, respectively, and the difference was statistically significant (P < 0.05). Among different age groups, the seroprevalence in cats varied from 1.9 to 7.9%, and that in dogs ranged from 9.6 to 20.4%; however, the differences were not statistically significant (P > 0.05). CONCLUSIONS: This is the first report of the seroprevalence of C. felis exposure in cats and dogs in Lanzhou, northwestern China. Our results indicate that the presence of C. felis exposure in cats and dogs may pose a potential threat to human health.BMC Veterinary Research 05/2013; 9(1):104. · 1.86 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Objective This study was aimed at investigating the frequency of infection by Cp. psittaci and determining its genotype in individuals at potential risk of exposure to the bacteria. Methodology The study involved 170 individuals: a risk group (n= 96) and a low-risk control group (n=74). Cp. psittaci was detected and genotyped by single-tube nested PCR and ompA gene sequencing. Results Eight (8.3 %) positive cases were detected in the risk group and 1 (1.4 %) in the control group (p<0.04). Cp. psittaci was found in 16.7 % of pigeons' fecal samples. Cp. psittaci infection with was more frequent in symptomatic (17.7 %) than asymptomatic (6.3 %) individuals in the risk group. Analysing the genomes isolated from human and bird specimens revealed the presence of genotype B. Conclusion The presence of Cp. psittaci genotype B in the population being evaluated could have been attributed to zoonotic transmission from pigeons to humans, an underestimated potential public health problem in Venezuela requiring the health authorities' involvement.Revista de salud publica (Bogota, Colombia) 04/2012; 14(2):305-14.
- [Show abstract] [Hide abstract]
ABSTRACT: Human psittacosis caused by Chlamydophila psittaci is one of the most common zoonotic atypical pneumonias featuring pulmonary as well as extrapulmonary infections. Most of the cases involve avian contact history especially with psittacine birds. Herein we report a 44-year-old male patient displaying atypical pneumonia symptoms of intermittent fever, dry cough, chest pain, dyspnea, headache, hepatitis, and hyponatremia. He had two sick cockatiels, one of which had died a month previously. A microimmunofluorescence test was performed to check the serum antibody levels against Chlamydophila psittaci. The serum IgM titer showed positive titer of 1:256, 1:256, and 1:128 on Days 11, 23, and 43 after disease onset, respectively. His fever subsided soon and clinical symptoms improved after minocycline was administrated on Day 12. The psittacosis case was confirmed by history of psittacine bird contact, clinical symptoms, treatment response, and positive IgM titer. To our knowledge, this is the first report of a psittacosis case in Taiwan.Journal of the Formosan Medical Association 07/2013; 112(7):430-3. · 1.00 Impact Factor