Early treatment of multiple sclerosis to prevent neurologic damage

MS Comprehensive Care Center, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
Neurology (Impact Factor: 8.29). 12/2008; 71(24 Suppl 3):S3-7. DOI: 10.1212/WNL.0b013e31818f3d6f
Source: PubMed


Multiple sclerosis (MS) involves ongoing accumulating CNS damage. Precisely which environmental factors trigger onset and progression of the disease are not known. However, clinical trials indicate benefits from early use of disease-modifying therapies (DMTs). All the completed clinically isolated syndrome trials (CHAMPS, ETOMS, BENEFIT, PRECISE) reported significant suppression of subsequent relapse and MRI lesion formation from use of DMT at the first relapse. This article reviews data on early treatment. Such an approach requires the ability to recognize clinically isolated syndrome features that indicate a diagnosis of MS.

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    • "Although most clinical studies assess efficacy of disease modifying agents focusing on physical disability and radiological follow up, evidence exists that the specific pharmacological options for MS have a positive effect on patients' QoL. Moreover, several specialists argue that early pharmacological intervention is indicated in order to prevent inflammatory neurological damage and to delay disease progression (Coyle, 2008). IFN in patients with clinically isolated syndrome has proven to lengthen time to conversion into definite MS. "
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