Obesity and the metabolic syndrome in developing countries.
ABSTRACT Prevalence of obesity and the metabolic syndrome is rapidly increasing in developing countries, leading to increased morbidity and mortality due to type 2 diabetes mellitus (T2DM) and cardiovascular disease.
Literature search was carried out using the terms obesity, insulin resistance, the metabolic syndrome, diabetes, dyslipidemia, nutrition, physical activity, and developing countries, from PubMed from 1966 to June 2008 and from web sites and published documents of the World Health Organization and Food and Agricultural Organization.
With improvement in economic situation in developing countries, increasing prevalence of obesity and the metabolic syndrome is seen in adults and particularly in children. The main causes are increasing urbanization, nutrition transition, and reduced physical activity. Furthermore, aggressive community nutrition intervention programs for undernourished children may increase obesity. Some evidence suggests that widely prevalent perinatal undernutrition and childhood catch-up obesity may play a role in adult-onset metabolic syndrome and T2DM. The economic cost of obesity and related diseases in developing countries, having meager health budgets is enormous.
To prevent increasing morbidity and mortality due to obesity-related T2DM and cardiovascular disease in developing countries, there is an urgent need to initiate large-scale community intervention programs focusing on increased physical activity and healthier food options, particularly for children. International health agencies and respective government should intensively focus on primordial and primary prevention programs for obesity and the metabolic syndrome in developing countries.
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ABSTRACT: Obesity is a major public health concern. This condition results from a constant and complex interplay between predisposing genes and environmental stimuli. Current attempts to manage obesity have been moderately effective and a better understanding of the etiology of obesity is required for the development of more successful and personalized prevention and treatment options. To that effect, mouse models have been an essential tool in expanding our understanding of obesity, due to the availability of their complete genome sequence, genetically identified and defined strains, various tools for genetic manipulation and the accessibility of target tissues for obesity that are not easily attainable from humans. Our knowledge of monogenic obesity in humans greatly benefited from the mouse obesity genetics field. Genes underlying highly penetrant forms of monogenic obesity are part of the leptin-melanocortin pathway in the hypothalamus. Recently, hypothesis-generating genome-wide association studies for polygenic obesity traits in humans have led to the identification of 119 common gene variants with modest effect, most of them having an unknown function. These discoveries have led to novel animal models and have illuminated new biologic pathways. Integrated mouse-human genetic approaches have firmly established new obesity candidate genes. Innovative strategies recently developed by scientists are described in this review to accelerate the identification of causal genes and deepen our understanding of obesity etiology. An exhaustive dissection of the molecular roots of obesity may ultimately help to tackle the growing obesity epidemic worldwide.01/2015; 3:e856. DOI:10.7717/peerj.856
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ABSTRACT: Objective: The metabolic syndrome (MetS) has become one of the major public-health challenges worldwide. Early identification of metabolic complications consist an essential target for youth public health. We aimed to evaluate the prevalence of MetS and its components among overweight and obese adolescents. Methods: This cross-sectional study concerned 51 overweight and obese adolescents. Anthropometric assessments, blood pressure measurement and biochemical assessment were done. MetS was defined according to the International Diabetes Federation (IDF) criteria. All data were collected during one academic school year in 2012 and 2013. Results: The prevalence of the MetS was 21.6%. There was no gender difference in prevalence of MetS (P=0.09). Obese subjects had the highest proportion of MetS than overweight (25% vs. 15.8%; p=0.04). 35.3% of subjects had at least two abnormalities of MetS. Abdominal obesity was the most common individual component of the MetS (91.3 %) followed by low HDL cholesterol (58.8%). Body mass index (BMI), Waist circumference (WC), Waist to hip ratio (WRH) and Neck circumference (NC) had partial positive correlation with Blood pressure (BP), and Triglyceride. Similarly, (BP), Triglyceride and HDL cholesterol were significantly higher in subjects with metabolic syndrome than that of subjects without metabolic syndrome (p < 0.05). Conclusion: MetS is prevalent in our young population in Sfax City. The results of this study will help in planning to control these problems in the future. So we suggest screening programs for secondary school adolescent to control obesity and MetS in Tunisia.03/2015; 3(1):1-6. DOI:10.12691/ijcn-3-1-1