Article

Compensatory evolution in diploid populations.

Department of Contemporary Liberal Arts, Junior College, Chikushi Jogakuen University, 2-12-1 Ishizaka, Dazaifu-shi, Fukuoka-ken 818-0192, Japan.
Theoretical Population Biology (impact factor: 1.65). 09/2008; 74(2):199-207. DOI:10.1016/j.tpb.2008.07.002 pp.199-207
Source: PubMed

ABSTRACT Compensatory mutations are individually deleterious but harmless in appropriate combinations either at more than two sites within a gene or on separate genes. Considering that dominance effects of selection and heterodimer formation of gene products may affect the rate of compensatory evolution, we investigate compensatory neutral mutation models for diploid populations. Our theoretical analysis on the average time until fixation of compensatory mutations shows that these factors play an important role in reducing the fixation time of compensatory mutations if mutation rates are not low. Compensatory evolution of heterodimers is shown to occur more easily if the deleterious effects of single mutants are recessive.

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Keywords

appropriate combinations
 
compensatory evolution
 
Compensatory mutations
 
compensatory neutral mutation models
 
deleterious effects
 
diploid populations
 
fixation
 
fixation time
 
gene products
 
heterodimers
 
mutation rates
 
separate genes
 
single mutants
 
theoretical analysis
 
two sites