Article

QRS voltages are transiently increased at the superacute stage of experimental myocarditis.

Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto.
Experimental and clinical cardiology (impact factor: 0.58). 01/2008; 13(1):15-8. pp.15-8
Source: PubMed

ABSTRACT There are few reports on the precise electrocardiographic characteristics of acute myocarditis. The present study was focused on QRS voltage changes at the superacute stage of murine myocarditis.
Serial electrocardiograms were recorded during the acute stage of viral myocarditis in mice, and then the cardiac pathology was examined. After recording baseline electrocardiograms, mice (n=235) were inoculated intraperitoneally with the encephalomyocarditis virus, resulting in severe myocarditis. Electrocardiograms were serially recorded until nine days after virus inoculation (superacute stage, days 3 to 6; acute stage, days 7 to 9). Changes in heart rate and QRS voltages were analyzed.
Serial electrocardiograms revealed that heart rates began to increase after day 3, and that the sum of the QRS voltages increased on day 3 and then decreased on days 7 to 9. Trivial mononuclear cell infiltrations and interstitial edema were most frequently found in mice at the superacute stage.
Transient increase of the QRS voltages at the superacute stage of myocarditis was demonstrated, which may be due to an increase in ventricular mass caused by interstitial edema at this stage.

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Keywords

cardiac pathology
 
day 3
 
days 3
 
days 7
 
Electrocardiograms
 
encephalomyocarditis virus
 
heart rate
 
heart rates
 
interstitial edema
 
precise electrocardiographic characteristics
 
QRS voltage changes
 
QRS voltages
 
recording baseline electrocardiograms
 
reports
 
Serial electrocardiograms
 
superacute stage
 
Trivial mononuclear cell infiltrations
 
ventricular mass
 
virus inoculation