Article

Overview of factors contributing to the pathophysiology of progressive renal disease

Renal Division, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Kidney International (Impact Factor: 8.52). 10/2008; 74(7):860-6. DOI: 10.1038/ki.2008.351
Source: PubMed

ABSTRACT Some basic premises must be considered when validating hypothesis about progression of renal disease. In an accompanying series of five articles, specific aspects of progression will be reviewed by experts in the field: mechanisms of tissue and matrix remodelling; interstitial fibrosis; the contribution of ischemia and hypoxia; the role and type of the inflammatory infiltrate; and, finally, glomerular sclerosis.

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