Article

Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management

Second Department of Internal Medicine Propaedeutic, Athens University Medical School, University General Hospital Attikon, Haidari, Greece.
Annals of Oncology (Impact Factor: 6.58). 12/2008; 19(12):1992-9. DOI: 10.1093/annonc/mdn525
Source: PubMed

ABSTRACT Gastrointestinal lymphoma is the most common form of extranodal lymphoma, accounting for 30%–40% of cases. The most commonly
involved site is the stomach (60%–75% of cases), followed by the small bowel, ileum, cecum, colon and rectum. The most common
histological subtypes are diffuse large B-cell lymphoma (DLBCL) and marginal zone B-cell lymphoma of the mucosa-associated
lymphoid tissue (MALT). Helicobacter pylori infection has been implicated in the pathogenesis of MALT gastric lymphoma, but its role in gastric diffuse large B-cell
non-Hodgkin's lymphoma (NHL) is controversial. The therapeutic approach for patients with gastric NHL has been revised over
the last 10 years. Conservative treatment with anthracycline-based chemotherapy alone or in combination with involved-field
radiotherapy has replaced gastrectomy as standard therapy in cases with DLBCL. Additionally, MALT lymphomas are mainly treated
with antibiotics alone, which can induce lasting remissions in those cases associated with H. pylori infection. Nevertheless, various therapeutic aspects for primary gastric lymphomas are still controversial and several questions
remain unanswered. Among others, the role of rituximab, consolidation radiotherapy as well as H. pylori eradication in histological aggressive subtypes warrants better clarification.

Download full-text

Full-text

Available from: Sotirios Papageorgiou, Jul 04, 2015
0 Followers
 · 
135 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas. A 68-year-old male with a prior diagnosis of colon non-Hodgkin lymphoma (NHL) was admitted to the hospital with a complaint of cough, sputum, and dyspnea. The chest radiograph showed right hilar enlargement and opacity at the right middle zone suggestive of a mass lesion. Computed tomography of thorax revealed a right-sided mass lesion extending to thoracic wall with the destruction of the third and the fourth ribs and a right hilar mass lesion. Fiberoptic bronchoscopy was performed in order to evaluate endobronchial involvement and showed stenosis with mucosal tumor infiltration in right upper lobe bronchus. The pathological examination of bronchoscopic biopsy specimen reported diffuse large B-cell lymphoma and the patient was accepted as the endobronchial recurrence of sigmoid colon NHL. The patient is still under treatment of R-ICE (rituximab-ifosfamide-carboplatin-etoposide) chemotherapy and partial regression of pulmonary lesions was noted after 3 courses of treatment.
    09/2013; 2013:794642. DOI:10.1155/2013/794642
  • Source
    Systemic Lupus Erythematosus, 03/2012; , ISBN: 978-953-51-0266-3
  • [Show abstract] [Hide abstract]
    ABSTRACT: 摘要 目的:探讨接受以铂类为基础的联合化疗的Ⅳ期胃癌患者的预后因素。方法:回顾性分析伴有远处转 移并接受一周期或者一周期以上的以铂类为基础联合化疗的Ⅳ期胃癌患者共138例,生存率的计算采用Ka- plan-Meier法,各亚组生存率差别的比较采用log-rank时序检验,采用Cox比例分析模型作其对生存率影响的多因 素分析,并根据其结果结合有意义的预后因素推导出预后指数的计算方法。结果:1)单因素及Cox比例分析模型多 因素分析发现ECOG评分(P=0.001)、体重减轻(P=0.001)、浸润深度(P=0.000)、腹膜转移(P=0.005)、转移灶数目(P= 0.029)和血清总胆红素升高(P=0.018)为影响生存期的独立预后因素(P