Thyroid-stimulating hormone and follicle-stimulating hormone status in Hispanic women during the menopause transition.
ABSTRACT Few studies exist on thyroid status and ovarian dysfunction, although the prevalence of thyroid disease, particularly hypothyroidism, increases with advanced age and is more common in women. Loss of ovarian function is a lengthy process, and it is well known that follicle-stimulating hormone (FSH) increases with age and is correlated with loss of ovarian reserves. Limited information is available on FSH and thyroid-stimulating hormone (TSH) status in healthy euthyroid women in pre- and postmenopause states. We propose that patterns in FSH levels depend on the menopause state and that a possible relationship with TSH is present in mature women.
Baseline data from the study Health and Menopause in Hispanic Women in Puerto Rico were used. Eligible women were 30-84 years old. Demographic data and lifestyle and health information were collected through a questionnaire, and blood chemistries were analyzed.
In women without thyroid disease, the median TSH was 1.97 mIU/L, and for euthyroid women the median was 1.84 mIU/L; no difference was observed between pre- and postmenopause states. A positive tendency was found between FSH levels and age in this group.
This report compares the value of TSH in Puerto Rican women during pre- and postmenopausal states, and our findings are different from those in other ethnic groups. FSH levels correlate with age, and the general tendency of FSH to increase with age differs according to menopause state. No correlation between TSH and FSH levels was found in this study.
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ABSTRACT: Interest in menopausal symptoms in general and hot flushes (HFs) in particular has grown in recent years. This is mostly due to increased awareness and the vast impact these symptoms have on women's lives. Despite the high prevalence of women who experience HFs, a definitive etiology for HFs is yet to be found. Our objective was to review the current literature dealing with associated factors for experiencing HFs and to provide a synthesized overview on this common and often debilitating condition. We systematically searched the English-language literature in the PubMed database using relevant key words and included only those articles that contained information on associated factors for HFs in generally healthy midlife women. Both conflicting scientific results between studies documenting factors that influence HFs and the lack of validated measuring tools make it difficult to truly pinpoint associated factors for HFs. Nonetheless, we identified the following clusters of associated factors: the menopausal stages, sex steroid hormones, other endocrine agents, genetic polymorphisms, race/ethnicity, body mass index (BMI) and obesity, mood disorders, smoking, soy isoflavones and phytoestrogens, alcohol consumption, and physical activity. No single associated factor was consistently identified as having a major role in experiencing HFs. More resources should be directed to develop a unified study system along with multivariable analyses to get a better understanding of this condition, which often imposes a tremendous social and personal toll on the women who experience it.Journal of Women's Health 10/2010; 19(10):1905-14. DOI:10.1089/jwh.2009.1852 · 1.90 Impact Factor