Article

Surgical technique and systemic inflammation influences long-term disease-free survival following hepatic resection for colorectal metastasis.

Hepatobiliary and Transplantation Unit, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Journal of Surgical Oncology (impact factor: 2.1). 10/2008; 98(5):371-6. DOI:10.1002/jso.21103
Source: PubMed

ABSTRACT To date, there is limited data available on prognostic factors that influence long-term disease-free survival following hepatic resection for colorectal liver metastasis (CRLM). The aim of the study was to identify prognostic factors that were associated with long-term disease-free survival (>5 years) following resection for CRLM.
Patients undergoing resection for CRLM from January 1993 to March 2007 were identified from the hepatobiliary database. Data analyzed included demographics, laboratory results, operative findings and histopathological data.
Seven hundred five curative primary hepatic resections were performed, of which 434 patients developed disease recurrence within 5 years and 67 patients were disease-free more than 5 years. There was a significant association between systemic inflammatory response (raised neutrophil to lymphocyte ratio and/or C-reactive protein), blood transfusion, >2 tumors, bilobar disease and resection margin involvement with developing recurrence during the follow-up period. On multivariate analysis, three independent predictors for recurrent disease within the 5-year follow-up were identified: pre-operative inflammatory response; blood transfusion requirement; and status of resection margin.
Absence of a systemic inflammatory response and surgical technique to minimize transfusion requirements and obtain a R0 resection margin, are associated with long-term disease-free survival.

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    Article: Radiofrequency ablation as first-line treatment in patients with early colorectal liver metastases amenable to surgery.
    Gerd Otto, Christoph Düber, Maria Hoppe-Lotichius, Jochem König, Michael Heise, Michael Bernhard Pitton
    [show abstract] [hide abstract]
    ABSTRACT: Aiming at avoidance of futile surgery, we have tested whether radiofrequency ablation (RFA) may be used as first-line treatment in patients with colorectal metastases (CRLM) occurring within the first year after colorectal surgery. Surgical resection is the standard treatment in patients with CRLM. Major retrospective analyses have identified the interval between colorectal surgery and the occurrence of CRLM to be of prognostic importance. So far, it is unknown whether survival of the respective patients is hampered if RFA is used as first-line treatment. According to a clinical pathway, we have treated patients with CRLM detected within the first year after colorectal surgery preferentially by RFA (n=28). Resection (n=82) was performed in patients who were deemed not amenable to RFA due to number, size, or location of metastatic lesions. The diameter of lesions differed between the groups. All other characteristics of patients and lesions were comparable. Local recurrence and new hepatic lesions were treated with repeated RFA or surgery whenever possible. Local recurrence at the site of ablation or resection occurred in 32% and 4% (P<0.001), new metastases apart from the site of previous treatment in 50% and 34% (P=0.179), and systemic recurrence in 32% and 37% (P=0.820) of the patients after RFA and surgery, respectively. Time to progression was significantly shorter in patients primarily treated with RFA (203 vs. 416 days; P=0.017). After primary treatment, 9 RFA patients and 8 surgery patients were amenable to repeated RFA or repeated surgery resulting in identical rates of disease-free patients and identical 3-year overall survival in both treatment groups: 67% and 60%, respectively; P=0.93. Despite striking differences in local tumor recurrence and shorter time to progression, survival in patients with early CRLM does not depend on the mode of primary hepatic treatment.
    Annals of surgery 10/2009; 251(5):796-803. · 7.90 Impact Factor
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Keywords

5 years
 
blood transfusion
 
blood transfusion requirement
 
disease recurrence
 
follow-up period
 
hepatic resection
 
hepatobiliary database
 
histopathological data
 
independent predictors
 
influence long-term disease-free survival
 
long-term disease-free survival
 
minimize transfusion requirements
 
operative findings
 
Patients undergoing resection
 
pre-operative inflammatory response
 
R0 resection margin
 
resection margin
 
resection margin involvement
 
significant association
 
systemic inflammatory response