Regional body fat distribution and metabolic profile in postmenopausal women.

Institute of Nutraceuticals and Functional Foods, Laval University, Québec QC, Canada G1K 7P4.
Metabolism: clinical and experimental (Impact Factor: 3.61). 08/2008; 57(8):1101-7. DOI: 10.1016/j.metabol.2008.03.015
Source: PubMed

ABSTRACT The aim of the study was to examine how body fat distribution variables were associated with metabolic parameters in a sample of 113 postmenopausal women not receiving hormone therapy (56.9 +/- 4.4 years, 28.4 +/- 5.1 kg/m(2)). Body fat distribution variables (visceral adipose tissue [AT], subcutaneous AT, and total midthigh AT) were measured using computed tomography; body fat mass was assessed by hydrostatic weighing; insulin sensitivity was determined with the euglycemic-hyperinsulinemic clamp; fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) concentrations were measured by a 75-g oral glucose load; and (high-sensitivity) C-reactive protein (hs-CRP) was measured using a highly sensitive assay. After controlling for fat mass, visceral AT was positively associated with plasma triglyceride, hs-CRP, FPG, and 2hPG, and negatively associated with high-density lipoprotein cholesterol (HDL-C) and insulin sensitivity. Total midthigh AT was negatively associated with apolipoprotein B, FPG, and 2hPG, and positively associated with insulin sensitivity. Stepwise multiple regression analyses including abdominal visceral AT, subcutaneous AT and total midthigh AT as independent variables showed that abdominal visceral AT best predicted the variance in plasma triglyceride, HDL-C, low-density lipoprotein peak particle size, hs-CRP, FPG, 2hPG, and insulin sensitivity. Abdominal subcutaneous AT was a significant predictor of only insulin sensitivity, whereas total midthigh AT predicted HDL-C, low-density lipoprotein peak particle size, and apolipoprotein B. These multivariate analyses also indicated that total midthigh AT was favorably related to these outcomes, whereas abdominal visceral AT and subcutaneous AT were unfavorably related. These results confirmed that abdominal visceral fat is a critical correlate of metabolic parameters in postmenopausal women. In addition, a higher proportion of AT located in the total midthigh depot is associated with a favorable metabolic profile.

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    • "CVD is rarely seen in premenopausal women, but its incidence increases markedly after menopause [2]. Menopause is associated with increased body mass index (BMI) and redistribution of body fat in favor of abdominal adipose tissue [3]. Central distribution of body fat and menopause-induced estrogen deficiency leads to increased risk of cardiovascular and metabolic diseases [4]. "
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    ABSTRACT: Objective We designed a prospective case-control study in order to investigate the lipid profiles, insulin sensitivity, presence of metabolic syndrome (MetS) and the abdominal fat distribution in karyotypically normal women with premature ovarian insufficiency (POI). Methods Anthropometric measurements, FSH, estradiol, total testosterone (T), sex hormone binding globulin (SHBG), free androgen index (FAI), fasting glucose and insulin, homeostatic model for insulin resistance (HOMA-IR), lipid profile, the prevalence of MetS and ultrasonographic abdominal fat measurements were assessed in 56 women with POI and 59 healthy controls at the same age range. Results Serum levels of T, SHBG and FAI were not significantly different between both groups. Total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were higher in women with POI. There were no differences in glucose, insulin, HOMA-IR, low-density lipoprotein cholesterol (LDL-C), triglyceride levels between the two groups. A significant positive correlation was identified between T and TG and also between FAI and LDL-C; SHBG levels were correlated inversely with FSH, and positively with HDL-C in women with POI. The presence of MetS was significantly higher in women with POI. The subcutaneous, preperitoneal and visceral fat thicknesses were not significantly different between the groups. Conclusions Early cessation of ovulatory function may associated with higher levels of serum TC and HDL-C, but does not seem to cause differences in abdominal fat distribution in women with POI. POI is associated with higher risk of MetS.
    Maturitas 11/2014; 79(3). DOI:10.1016/j.maturitas.2014.07.008
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    • "Specifically, VFT as measured by ultrasonography and the VFT/SFT ratio decreased only in the responder group. The relationship between CRP and abdominal adiposity has been reported in several studies [21] [22] [23] [24] [25] [26]. A recent study with 1250 Framingham Offspring Study participants (10% diabetic patients) using volumetric multidetector CT showed that both subcutaneous adipose tissue and visceral adipose tissue are associated with plasma inflammatory markers including CRP and that the association for visceral adipose tissue is stronger [23]. "
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    Metabolism: clinical and experimental 02/2011; 60(2):165-72. DOI:10.1016/j.metabol.2009.12.007
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    • "The distribution of body fat is an area of clinical and research interest because of the relationships between AF and metabolic syndrome (Lee et al., 2008; Berends et al., 2009), and between GF and a favourable metabolic profile (Lee et al., 2008; Piche et al., 2008). We found an excellent level of precision for measurements of GF, which was lower (Rezzi et al., 2009) or similar (Toussinot et al., 2007) to CVs reported elsewhere. "
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    European journal of clinical nutrition 01/2011; 65(1):140-2. DOI:10.1038/ejcn.2010.190
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