Article

Interaction between warfarin and Panax ginseng in ischemic stroke patients.

Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Journal of alternative and complementary medicine (New York, N.Y.) (Impact Factor: 1.52). 07/2008; 14(6):715-21. DOI: 10.1089/acm.2007.0799
Source: PubMed

ABSTRACT Today, the combined use of Oriental herbal medicines and Western biomedical medicines has been a prevalent yet controversial practice. Case reports and healthy volunteer trials have had conflicting results on the effect Panax ginseng has on warfarin's pharmacologic action, some reporting a reductive and others a potentiating influence.
This study investigated the interaction between warfarin and P. ginseng by observing the prothrombin time (PT) and the international normalized ratio (INR) in ischemic stroke patients who did not have a history of taking warfarin.
Randomized, open-label, controlled study.
Twenty-five (25) patients newly diagnosed with ischemic stroke by brain computed tomography or magnetic resonance imaging in the Korean Medical Hospital, Kyung Hee University (Seoul, Republic of Korea).
Ischemic stroke patients were randomized into 2 groups: the ginseng group (n = 12), given both P. ginseng and warfarin, and the control group (n = 13), given only warfarin, both for 2 weeks. The warfarin dose was restricted to 2 mg in the first week and 5 mg in the second week.
The peak values and the international normalized ratio (INR) and prothrombin time (PT) areas under the curve (AUC) in both groups significantly increased compared to those at baseline. However, there was no statistically significant difference in peak values and INR and PT AUC between groups in both the first and second weeks.
This study suggests that coadministration of P. ginseng and warfarin in ischemic stroke patients does not influence the pharmacologic action of warfarin.

1 Follower
 · 
176 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Male white rabbits were fed a high cholesterol diet supplemented with red ginseng (RG) or red ginseng plus nattokinase (RGNK). RG and RGNK significantly reduced increased serum triglycerides levels and aortic plaque area in a hypercholesterol diet fed rabbits. Moreover, only RGNK reduced hepatic cholesterol and cholesteryl ester transfer protein activity levels. Therefore, the present study suggests RGNK might be a potential therapeutic approach for atherogenesis.
    Food science and biotechnology 02/2013; 23(1):283-287. DOI:10.1007/s10068-014-0039-y · 0.66 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In traditional Chinese medicine (TCM), the human body is divided into Yin and Yang. Diseases occur when the Yin and Yang balance is disrupted. Different herbs are used to restore this balance, achieving the goal of treatment. However, inherent difficulties in designing experimental trials have left much of TCM yet to be substantiated by science. Despite that, TCM not only remains a popular form of medical treatment among the Chinese, but is also gaining popularity in the West. This phenomenon has brought along with it increasing reports on herb-drug interactions, beckoning the attention of Western physicians, who will find it increasingly difficult to ignore the impact of TCM on Western therapies. This paper aims to facilitate the education of Western physicians on common Chinese herbs and raise awareness about potential interactions between these herbs and warfarin, a drug that is especially susceptible to herb-drug interactions due to its narrow therapeutic range.
    Singapore medical journal 01/2015; 56(1):11-18. DOI:10.11622/smedj.2015004 · 0.63 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Aim of the study: Warfarin is commonly used for preventing thromboembolic diseases. Care is taken when administering warfarin, since combined therapy with other substances can affect the prothrombin time international normalized ratio (INR). Whether warfarin interacts with herbal medicines remains controversial. This study aimed to examine the effect of herbal complexes on INR in patients being treated with warfarin. Methodology: We examined medical records of patients treated with a combination therapy of warfarin and herbal complexes from January 1, 2009 to December 31, 2010. We recorded changes in INR and tested the significance of the difference in INR using a paired T-test. Results: Twenty-eight patients were identified. INR did not change significantly in this group of patients (p = 0.615). In 1 case, a dramatic change in INR was observed. However, this did not appear to occur in relation to combined warfarin and herbal complex therapy. Conclusions: There is no strong evidence that herbal complexes have an influence on INR when taken in combination with warfarin. However, we propose that further evaluation of larger samples is required to reach a definite conclusion.
    European Journal of Integrative Medicine 12/2012; 4(4):e408-e412. DOI:10.1016/j.eujim.2012.05.002 · 0.65 Impact Factor