Article

Human papillomavirus genotype distribution in external acuminata condylomata: a Large French National Study (EDiTH IV).

Service de Dermatologie, Hospital University Saint Jacques, Besançon, France.
Clinical Infectious Diseases (impact factor: 9.15). 09/2008; 47(5):610-5. DOI:10.1086/590560 pp.610-5
Source: PubMed

ABSTRACT External acuminata condylomata (EAC) are among the most common sexually transmitted diseases. Although it is understood that low-risk human papillomavirus (HPV) genotypes 6 and 11 are associated with EAC, there have only been a few, small, published studies reporting the genotype-specific prevalence of HPV. The objective of our study was to assess the prevalence of HPV genotypes for a large number of cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in France.
A total of 256 women and 260 men who presented with EAC to French gynecologists, dermatologists, and proctologists were prospectively recruited during the period January through April 2007. Specimens were collected with a cytobrush, and the HPV genotype was determined using the INNO-LiPA assay (Innogenetics), which detects 24 HPV genotypes.
Four hundred twenty-three beta-globin-positive samples could be analyzed. The median age of patients was 30 years (range, 18-72 years). The overall prevalence of HPV DNA in patients with EAC was 99% (33% of patients were coinfected with another pathogen). Low-risk genotypes predominated, with a prevalence of 89%. The most prevalent genotypes were 6 (69%) and 11 (16%), followed by 16 (9%), 51 (8%), 52 (7%), 66 (6%) 53 (5%), 31 (3%), and 18 (3%). The cumulative prevalence of genotypes 6 and 11 was 83%, and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 88%.
This study is, to our knowledge, the first large, multicenter survey to provide solid data on HPV genotype distribution among patients with EAC. Our results provide strong evidence that, in France, the most prevalent HPV genotypes in persons with EAC are 6 and 11. Because of its 99% efficacy for the prevention of EAC and a vaccine coverage of 100%, the quadrivalent HPV vaccine could prevent 62%-87% of EAC cases in France.

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Keywords

cumulative prevalence
 
detects 24 HPV genotypes
 
External acuminata condylomata
 
first large
 
French gynecologists
 
genotype-specific prevalence
 
HPV DNA
 
HPV genotype
 
HPV genotype distribution
 
HPV genotypes
 
INNO-LiPA assay
 
Low-risk genotypes predominated
 
low-risk human papillomavirus
 
period January
 
potential benefit
 
prevalent genotypes
 
prevalent HPV genotypes
 
quadrivalent HPV vaccine
 
solid data
 
Specimens