Disturbances of self-other distinction after stimulation of the extrastriate body area in the human brain

University of Cologne, Cologne, Germany.
Social neuroscience (Impact Factor: 2.66). 02/2009; 4(1):40-8. DOI: 10.1080/17470910801938023
Source: PubMed


In a recent experiment with functional magnetic-resonance imaging, we found that brain activity in the extrastriate body area (EBA) distinguished between observed self- and other-generated movements, being significantly higher during observation of someone else's movement. Here, we investigated further the role of EBA in self-other distinctions using low-frequency repetitive transcranial magnetic stimulation (rTMS). As compared with rTMS applied over a control site, rTMS applied over the EBA increased reaction times, without affecting accuracy, for the detection of other-generated movements. Performance on a control motion-direction detection task was unaffected. These findings provide additional evidence for the role of the EBA in processing information necessary for identifying ourselves as agents of self-generated movements.

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    • "led researchers to investigate its possible role in self-other discrimination. For instance, David et al. [35] showed that low frequency rTMS on the EBA decreased the subjects' performance on self-other discrimination task. Similar results were found by disrupting the functioning of the inferior parietal lobule [36] or the superior parietal lobule [37]. "
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    ABSTRACT: Empathy is a multi-dimensional concept allowing humans to understand the emotions of others and respond adaptively from a social perspective. This mental process, essential to social interactions, has attracted the attention of many scholars from different fields of study but the blooming interest for empathy in cognitive neurosciences has rekindled this interest. This paper reviews the growing literature stemming from studies using brain stimulation techniques that have investigated directly or indirectly the different components of empathy, including resonance, self-other discrimination, and mentalizing. Some studies have also ventured toward the modulation of this complex process and toward the investigation of different components in populations that show reduced empathic skills. We argue that brain stimulation techniques have the potential to make a unique contribution to the field of empathy research with their exclusive capacity, compared to other brain imaging techniques, to modulate the neural systems involved in the distinct components of this process. Provided the development of innovative ecological paradigms that will put people in actual social interactions as well as comprehensive and adaptive models that can integrate research from different domains, the ultimate goal of this research domain is to devise protocols that can modulate empathy in people with developmental, neurological and psychiatric disorders.
    Brain Stimulation 03/2012; 5(2):95-102. DOI:10.1016/j.brs.2012.03.005 · 4.40 Impact Factor
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    • "David et al. (2007) argued that EBA not only represents visual stimulation but also integrates visual and motor signals. Furthermore, David et al. (2009) used TMS combined with a similar protocol to show that stimulation of EBA increased response times on the detection of incorrectfeedback trials. Closer examination (described in detail in Kontaris, Wiggett, & Downing, 2009) suggests, however, that TMS stimulation may have also influenced performance on a motion task that was used as a control, and hence these results may have reflected disruption of adjacent hMT+. "
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    Cognitive neuroscience 11/2011; 2(3-4):212-4. DOI:10.1080/17588928.2011.604725 · 2.65 Impact Factor
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    • "Ten years ago, a visual area located in the human occipito-temporal cortex was shown to respond selectively to body parts (extrastriate body area, EBA, [9]). More recently, the same area was proposed to perform a " sorting of body part images by identity " [19], either by itself [1] [5] [6] [19], or as part of a right hemisphere network [13] [14], thus adding to the rich neuroanatomical data on agency attribution [2] [7] [15] [16] [25]. "
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