A Comparison of Low-Dose and Normal-Dose Gadobutrol in MR Renography and Renal Angiography

Department of Radiology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Korean Journal of Radiology (Impact Factor: 1.57). 06/2008; 9(3):250-7. DOI: 10.3348/kjr.2008.9.3.250
Source: PubMed


It has been advocated that a reduced injection volume with highly concentrated (1 M) contrast material can produce a sharper bolus peak and an increased intravascular first-pass gadolinium concentration when compared with the use of a lower concentration (0.5 M). A higher concentration would also cause a reduction in dose. The purpose of our study was to test the use of a low dose (0.05 mmol/kg) of gadobutrol in magnetic resonance renography and angiography and compare the findings with a dose of 0.1 mmol/kg.
One-hundred-thirty-four patients referred for magnetic resonance angiography for suspected renovascular disease participated in the study. Contrast enhanced MR renography and angiography were performed after administration of a bolus of 0.1 mmol/kg or 0.05 mmol/kg gadobutrol in randomized patients. The relative signal intensity-time curves of the aorta, peripheral cortex and parenchyma, were obtained. Two radiologists evaluated the angiographic images and evaluated the quality of angiography.
The signal intensity with a low dose of gadobutrol was significantly lower in early phases, in the peripheral cortex (for 36, 54, 72 and 90 seconds), the parenchyma (for 36, 54, 72 seconds) and the aorta (for 18, 36, 54, 72 seconds). The decreases in the early phase obtained with a low dose of gadobutrol caused blunter time intensity curves. The difference in the quality scores of the readers for the angiographic images for the use of the two different doses was not statistically significant (p > 0.05).
A lower dose of gadobutrol can be used for MR renal angiography, but for MR renography the normal dose should be used.

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    • "However, to the best of our knowledge, there have been no reports of descriptions of renal parenchymal enhancement in previous studies. There is however a study about the parenchymal enhancement according to contrast media with different doses on MR renography (8). Contrary to other solid organs, the kidney excretes waste products, including contrast media, via the cortex, medulla, and pelvocalyceal system. "
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