Successive development of cutaneous polyarteritis nodosa, leucocytoclastic vasculitis and Sweet's syndrome in a patient with cervical lymphadenitis caused by Mycobacterium fortuitum.
ABSTRACT Mycobacterium fortuitum is a rapidly growing mycobacterium found in soil and water throughout the world. It can cause diseases in immunocompetent patients, usually resulting in localized skin and soft tissue infections. Cervical lymphadenitis caused by M. fortuitum is rare. We report a 46-year-old woman in whom skin lesions of cutaneous polyarteritis nodosa, leucocytoclastic vasculitis and Sweet's syndrome had successively developed before the diagnosis of cervical lymphadenitis caused by M. fortuitum was made. The skin lesions responded to colchicine and systemic corticosteroids but recurred intermittently. After establishment of the diagnosis, she received treatment with clarithromycin and ciprofloxacin. The cervical lymph nodes decreased in size 6 months later and no more new skin lesions were found.
Article: Síndrome de Sweet[Show abstract] [Hide abstract]
ABSTRACT: Sweet's syndrome (acute febril neutrophilic dermatosis) is an entity classified into neutrophilic dermatosis group, the dermatoses most frequently associated with internal diseases.Clinical manifestations of Sweet's syndrome include arthralgias and/or myalgias in 66% of cases. So, articular involvement is the commonest extracutaneous manifestation of Sweet's syndrome. Nevertheless, this involvement is usually moderate and limited to the episode of cutaneous lesions and rarely these patients are examined by the rheumatologist. Cases of arthritis, myositis and osteitis have been described associated with neutrophilic infiltrate of Sweet's syndrome in these organs.On the other hand, rarely this neutrophilic dermatosis that is a reactive dermatosis has been described associated with rheumatologic diseases including rheumathoid arthritis, lupus erythematosus, Behçet's disease, etc.Sweet's syndrome is a very important diagnosis because this neutrophilic dermatosis is associated with solid and hematologic tumours, inflammatory diseases, infectious diseases, drugs, etc. In this manner, when this dermatosis is present an adequate study to exclude these associations is necessary.Seminarios de la Fundación Española de Reumatología 09/2008; 9(3):174–183. DOI:10.1016/S1577-3566(08)74609-8
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ABSTRACT: Mycobacterium tuberculosis infection is a common infection in developing countries, including India. It can induce several cutaneous reactions such as erythema nodosum, and erythema induratum; however, association of tuberculosis with Sweet's syndrome (also known as acute febrile neutrophilic dermatosis) is extremely rare. Here we present an interesting case of sputum-positive pulmonary tuberculosis with Sweet's syndrome. A 55-year-old female who was receiving a regimen of four antitubercular drugs (isoniazid, rifampicin, pyrazinamide, ethambutol- HRZE) for six weeks for sputum-positive pulmonary tuberculosis developed new onset high-grade fever for 15 days along with multiple reddish brown plaques and nodules involving the face as well as all four limbs of the body. Histopathology of the skin lesion was suggestive of Sweet's syndrome. The patient responded well to immunosuppressive steroid therapy.The Journal of Infection in Developing Countries 05/2013; 7(5):417-20. DOI:10.3855/jidc.2606 · 1.27 Impact Factor
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ABSTRACT: Aberrant and dysregulated inflammation of human blood vessels, or vasculitis, results in narrowing of the vessel’s lumen (i.e., stenosis) or aneurysmal wall damage (i.e., sac-like deformity of the vessel wall). This heterogenous group of autoimmune conditions is very rare. The understanding of the potential role of microbiome and infectious pathogens in eliciting immunologic responses and disease pathogenesis is rapidly expanding in many disease states. The precise role of microbiota in vasculitis is yet to be determined, but poses an interesting field of research. Our focus is on the potential role that infections and the microbiome may play in blood vessel inflammation, i.e., vasculitis.12/2014; 1(3-4). DOI:10.1007/s40588-014-0008-5