Respiratory arrest in systemic lupus erythematosus due to phrenic nerve neuropathy

Clinical Immunology Unit, Department of Internal Medicine, Rogaland Central Hospital, Stavanger, Norway.
Lupus (Impact Factor: 2.2). 10/2004; 13(10):817-9. DOI: 10.1191/0961203304lu1070cr
Source: PubMed


Diaphragmatic weakness in patients with systemic lupus erythematosus (SLE) is a controversial issue and is claimed to have a neuropathic, myopathic or unknown pathogenesis. In this patient a predominantly motor neuropathy with diaphragmatic paralysis due to axonal involvement of the phrenic nerve was discovered and successfully treated with immunosuppressive drugs.

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    • "Peripheral neuropathy may be slowly progressive [11] or acutely devastating [12]. One longitudinal study shows no other factor associating neuropathy with lupus [12], but another reports that acute peripheral neuropathy may be associated with lupus nephritis under ciprofloxacin treatment [13]. "
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    ABSTRACT: Background and aim: The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. Methods: Data of 559 SLE-LN patients were collected retrospectively, including titers of autoantibodies, electrodiagnostic studies, and clinical manifestations. Results: The neurologic manifestations of the SLE-LN patients were diverse and nonspecific. The prevalence rate of peripheral polyneuropathy was 2.68%, of which about 73.33% was mixed sensory-motor polyneuropathy. Numbness and functional gastrointestinal problems were the most prevalent symptoms and these were noted in every subtype of peripheral neuropathy. Among all the serology markers, anti-Ro was significantly associated with neuropathy related to SLE (P = 0.009). Conclusion: Peripheral neuropathy among LN patients is rare and may be easily overlooked. This study demonstrated that positive anti-Ro antibody may imply neuropathy in LN patients. Thus, anti-Ro can be considered a biomarker that should be added to the panel of conventional autoantibodies in LN patients.
    BioMed Research International 04/2014; 2014:524940. DOI:10.1155/2014/524940 · 1.58 Impact Factor
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    ABSTRACT: Respiratory manifestations of systemic lupus erythematosus (SLE) are frequent. The 'shrinking lung syndrome' (SLS) represents a rare complication of SLE. The pathogenesis and therapy of the SLS remains controversial. We report a series of five consecutive cases with the SLS of which we provide a detailed description of the extent and dynamics of the response to corticosteroid therapy.
    Lupus 02/2005; 14(12):959-63. DOI:10.1191/0961203305lu2186cr · 2.20 Impact Factor
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    ABSTRACT: A 28-years old lady complains of self-limited episodes of relapsing knee arthritis of 48-72h of duration every 2 weeks. Immunological profile was all negative. At the same time, radiological images did not reveal any abnormality. She underwent to knee arthroscopy, however, a definite diagnosis was not reached. We discuss the differential diagnosis of relapsing arthritis.
    01/2007; 6(1):58-62. DOI:10.1016/S2173-5743(10)70012-5
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