Article

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice

Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Science (Impact Factor: 31.48). 10/2004; 306(5697):879-81. DOI: 10.1126/science.1101678
Source: PubMed

ABSTRACT Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.

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    • "See also Figure S8. Neuron 86, 1–14, May 6, 2015 ª2015 Elsevier Inc. 9 Please cite this article in press as: Nautiyal et al., Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity, Neuron (2015), http://dx.doi.org/10.1016/j.neuron.2015.03.041 adult phenotypes related to psychiatric disorders, including anxiety , depression, aggression, and antisocial personality disorder (Ansorge et al., 2004; Caspi et al., 2002, 2003; Dodge et al., 1990; Richardson-Jones et al., 2011). Aggressive behavior has been linked to developmental alterations in monoamine levels through disruptions in monoamine oxidase A (MAOA) activity. "
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