Article

Ovarian function before and after salpingectomy in artificial reproductive technology patients.

Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin 70300, Israel, affiliated with the Sackler Faculty of Medicine, Tel-Aviv University.
Human Reproduction (Impact Factor: 4.67). 01/2000; 15(1):142-4. DOI: 10.1093/humrep/15.1.142
Source: PubMed

ABSTRACT To determine the effect of the removal of the tube on ovarian function we studied 52 artificial reproduction technology cycles in 26 women before and after undergoing laparoscopic salpingectomy for ectopic pregnancy. Ovarian response was measured by the duration and quantity of human menopausal gonadotrophins used in the cycle, the pre-ovulatory concentrations of oestradiol, the number of oocytes retrieved, and the quality of the embryos. All parameters were compared between cycles carried out before and after salpingectomy as well as between affected and unaffected sides. Our findings show no significant difference in any of the parameters studied. We conclude that laparoscopic salpingectomy does not abate ovarian response in artificial reproduction technology cycles that follow the procedure.

0 Bookmarks
 · 
81 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the consequence of salpingectomy on ovarian reserve by measuring anti-Müllerian hormone (AMH) levels prior to in-vitro fertilization (IVF) treatment in salpingectomised compared with non-salpingectomised women with tubal-factor infertility, women with unexplained infertility and fertile control women, and to evaluate whether AMH levels could predict IVF outcome. Cross-sectional study extended from a previousl prospective study. Four university fertility clinics. Seventy-one women with infertility and 21 fertile controls. Blood sampling and IVF and embryo transfer in the following cycle. Serum AMH levels and oocytes retrieved. AMH levels were significantly lower in the salpingectomy infertility group (median 16.1, range 5.2-54 pmol/l) compared to the non-salpingectomy tubal-factor infertility group (median 23.4, range 3.5-50 pmol/l; p=0.04). In all groups, AMH levels correlated positively with the number of oocytes retrieved. AMH predicted poor response (≤5 oocytes) with a sensitivity and specificity of 90% and 70%, at a 19 pmol/l cut-off value. Serum AMH levels were lower in salpingectomised women compared to women with tubal-factor infertility and preserved Fallopian tubes, indicating that ovarian reserve might be affected by tubal surgery. Furthermore, serum AMH levels could predict a poor oocyte response (<5 oocytes) in the study group of infertile women. This article is protected by copyright. All rights reserved.
    Acta Obstetricia Et Gynecologica Scandinavica 08/2013; · 1.85 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hysterectomy for benign conditions can be combined with bilateral salpingectomy to prevent re-intervention for malignant or benign fallopian tube pathologies. The objective of this study was to evaluate the benefit of prophylactic bilateral salpingectomy (PBS) in standard hysterectomy in premenopausal women. This retrospective cohort study included all premenopausal patients at our institution who underwent laparoscopically assisted vaginal hysterectomy (LAVH) without oophorectomy for benign pathologies between 2001 and 2007 [PBS group (LAVH + PBS), 2006-2007; non-PBS group (LAVH without PBS), 2001-2005]. Electronic and paper-based files as well as questionnaire responses were analyzed. In 2010, a survey on patients of a non-BRCA background with and without PBS was requested to complete a standardized questionnaire. Data were analyzed for differences between both subgroups regarding surgical outcome and adnexal pathologies as reported in the postoperative follow-up. Surgical outcomes of 540 patients (PBS: 127; non-PBS: 413) revealed no difference between groups. No preneoplastic or malignant lesions were diagnosed in the fallopian tubes. Follow-up (non-PBS 92 months, PBS 55 months; p < 0.01) responses from 295 (54.6 %) patients showed a higher incidence of benign adnexal pathologies in the non-PBS group (26.9 vs. 13.9 %; p = 0.02). The rate of LAVH-related surgical re-intervention was higher in the non-PBS group (12.56 vs. 4.16 %; p = 0.04). No malignant neoplasm was reported in the cohort. PBS did not increase the complication rate and reduced the incidence of adnexal pathologies requiring surgical re-intervention. Prospective trials should clarify the impact of PBS on cancer mortality.
    Journal of Cancer Research and Clinical Oncology 02/2014; · 2.91 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the effects of single, multiple dose methotrexate (MTX) administration and salpingectomy on ovarian reserve in a rat model.
    European journal of obstetrics, gynecology, and reproductive biology. 08/2014; 181C:205-209.