Article

Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma.

Centre Pluridisciplinaire d'Oncologie, School of Medicine, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Switzerland.
Nature Medicine (Impact Factor: 28.05). 04/1998; 4(4):408-14.
Source: PubMed

ABSTRACT Administration of tumor necrosis factor (TNF) and gamma interferon (IFN-gamma) to melanoma patients causes selective disruption of the tumor vasculature but the mechanism of this disruption is unknown. Here we report that exposure of human endothelial cells to TNF and IFN-gamma results in a reduced activation of integrin alphaVbeta3, an adhesion receptor that plays a key role in tumor angiogenesis, leading to a decreased alphaVbeta3-dependent endothelial cell adhesion and survival. Detachment and apoptosis of angiogenic endothelial cells was demonstrated in vivo in melanoma metastases of patients treated with TNF and IFN-gamma. These results implicate integrin alphaVbeta3 in the anti-vascular activity of TNF and IFN-gamma and demonstrate a new mechanism by which cytokines control cell adhesion.

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    • "Indeed, radiological studies demonstrated the selective disappearance of tumour hypervascularized areas after treatment with TNF-α [7]. Moreover, the tumour vascular disruption correlates in vivo with the induction of endothelial cell apoptosis [8] and in vitro with the specific suppression of αVβ3-mediated endothelial cell adhesion [9]. More recently, it has been demonstrated that VE-cadherin is a target of TNF-α, leading to the alteration of vascular integrity and tumour viability [10]. "
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