Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1988; 21 (S1): S5–S19

Department of Medicine, University of Vermont, Burlington, Vermont, United States
Diabetes Care (Impact Factor: 8.42). 03/1998; 21(3):467-8. DOI: 10.2337/diacare.21.3.467
Source: PubMed
Download full-text


Available from: Patrick M Catalano,
  • Source
    • "Hypertension was defined as a blood pressure >140/90 mmHg or as use antihypertensive drugs. Diabetes mellitus was defined as a fasting glucose ≥126 mg/dL or as use hypoglycemic drugs [19]. Patients smokers if they were current smokers or had stopped smoking since less than a year. "
    [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to assess if proton pump inhibitors (PPIs) may reduce the effectiveness of clopidogrel, than H2 antagonist (anti-H2) in order to determine rehospitalization for acute coronary syndrome (re-ACS), target vessel revascularization (TVR) and cardiac death. This case-control study included 176 patients with ACS undergoing angioplasty (PCI) with drug-eluting stent implantation. The population was divided into two groups: PPI group (n = 121) consisting of patients receiving at discharge dual antiplatelet therapy (DAT) plus PPI and anti-H2 group (n = 55), consisting of patients receiving at discharge DAT + H2 receptor antagonist (H2RA). In a followup of 36 months the prevalence of ACS event (P = 0.014), TVR (P = 0.031) was higher in the PPI group than in the anti-H2 group; instead there was no statistically significant difference between groups for death. The variables independently associated with ACS were the diabetes, omeprazole, and esomeprazole; instead the variables independently associated with TVR were only omeprazole. Our data shows that the use of omeprazole and esomeprazole, with clopidogrel, is associated with increased risk of adverse outcomes after PCI with drug-eluting stent implantation.
    06/2012; 2012:692761. DOI:10.5402/2012/692761
  • Source
    • "Diabetes in bank voles was first indicated during a study of stereotypic behavior in bank voles [20] [21]. In the present study, we found that one third of the wild bank voles trapped alive and brought to the laboratory developed clinical diabetes with hyperglycemia, ketonemia, ketonuria, hyperlipidemia , and weight loss, all criteria that are consistent with a clinical classification of type 1 diabetes [32]. The classification was supported by the observation that the diabetic voles had increased levels of GAD65, IA-2, and insulin autoantibodies detected with the same internationally standardized methods that are used to predict type 1 diabetes in humans [1] [4]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P = .03) autoantibodies. Affected islets stained positive for Ljungan virus, a novel picorna virus isolated from bank voles. Ljungan virus inoculation of nondiabetic wild bank voles induced beta-cell lysis. Compared to group A bank voles, Ljungan virus antibodies were increased in both nondiabetic (P < .0001) and diabetic (P = .0015) group B bank voles. Levels of Ljungan virus antibodies were also increased in young age at onset of newly diagnosed type 1 diabetes in children (P < .01). These findings support the hypothesis that the development of type 1 diabetes in captured wild bank voles is associated with Ljungan virus. It is speculated that bank voles may have a possible zoonotic role as a reservoir and vector for virus that may contribute to the incidence of type 1 diabetes in humans.
    Experimental Diabesity Research 01/2003; 4(1):35-44. DOI:10.1080/15438600303733
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To present recommendations for the certified athletic trainer in the management of type 1 diabetes in the athlete. In managing diabetes, the most important goal is to keep blood glucose levels at or as close to normal levels as possible without causing hypoglycemia. This goal requires the maintenance of a delicate balance among hypoglycemia, euglycemia, and hyperglycemia, which is often more challenging in the athlete due to the demands of physical activity and competition. However, effectively managing blood glucose, lipid, and blood pressure levels is necessary to ensuring the long-term health and well-being of the athlete with diabetes. These recommendations are intended to provide the certified athletic trainer participating in the management of an athlete with type 1 diabetes mellitus with the specific knowledge and problem-solving skills needed. Athletic trainers have more contact with the athlete with diabetes than most members of the diabetes management team do and so must be prepared to assist the athlete as required.
    Journal of athletic training 10/2007; 42(4):536-45. · 2.02 Impact Factor
Show more