Article

Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
Journal of Thoracic and Cardiovascular Surgery (impact factor: 3.41). 03/1998; 115(3):528-35. pp.528-35
Source: PubMed

ABSTRACT Neonatal and infant cardiopulmonary bypass results in multiorgan system dysfunction. Organ protective strategies have traditionally been directed at the myocardium and brain while neglecting the sometimes severe injury to the lungs. We hypothesized that liquid ventilation would improve pulmonary function and cardiac output in neonates after cardiopulmonary bypass.
Twenty neonatal swine were randomized to receive cardiopulmonary bypass with or without liquid ventilation. In the liquid-ventilated group, a single dose of perflubron was administered before bypass. The control group was conventionally ventilated. Each animal was placed on nonpulsatile, hypothermic bypass. Low-flow cardiopulmonary bypass was performed for 60 minutes. The flow rate was returned to 125 ml/kg per minute, and after warming to 37 degrees C, the animals were removed from bypass. Hemodynamic and ventilatory data were obtained after bypass to assess the effects of liquid ventilation.
Without liquid ventilation, cardiopulmonary bypass resulted in a significant decrease in cardiac output, oxygen delivery, and static pulmonary compliance compared with prebypass values. Input pulmonary resistance and characteristic impedance increased in these control animals. At 30, 60, and 90 minutes after bypass, the animals receiving liquid ventilation showed significantly increased cardiac output and static compliance and significantly decreased input pulmonary resistance and characteristic impedance compared with control animals not receiving liquid ventilation.
Liquid ventilation improved pulmonary function after neonatal cardiopulmonary bypass while increasing cardiac output. The morbidity associated with cardiopulmonary bypass may be significantly reduced if the adverse pulmonary sequelae of bypass can be diminished. Liquid ventilation may become an important technique to protect the lungs from the deleterious effects of cardiopulmonary bypass.

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    Article: Total liquid ventilation reduces lung injury in piglets after cardiopulmonary bypass.
    Lijun Jiang, Qiang Wang, Yinglong Liu, Ming Du, Xiangdong Shen, Xiaogang Guo, Song Wu
    [show abstract] [hide abstract]
    ABSTRACT: Cardiopulmonary bypass may cause lung injury that does not respond to traditional therapies. Total liquid ventilation has been developed as an alternative ventilatory strategy for severe lung injury. The aim of this study is to investigate the effect of total liquid ventilation on lung injury in piglets after cardiopulmonary bypass. After exposure to 60 minutes of cardiac arrest and weaning from cardiopulmonary bypass, 12 piglets (4.2 +/- 0.3 kg) were randomly treated with conventional gas ventilation (control group) or total liquid ventilation (study group) for 240 minutes. Samples for blood gas analysis were collected before, and at 30-minute intervals after, cardiopulmonary bypass. The degree of lung injury was quantified by histologic examination. The inflammatory cells and the levels of interleukin-6, interleukin-8, and myeloperoxidase in bronchoalveolar lavage were analyzed. Neutrophil and macrophage count in bronchoalveolar lavage were significantly decreased in the study group (52.4 +/- 6.82 vs 0.46 +/- 0.11 10(4)/mL; 58.33 +/- 0.88 vs 4.37 +/- 0.90 10(5)/mL; p < 0.001, respectively). The inflammation score and the total lung injury score were also reduced in the study group (4.39 +/- 1.14 vs 2.61 +/- 1.09; 11.06 +/- 1.66 vs 6.94 +/- 1.43; p < 0.05, respectively). The concentrations of interleukin-6 and myeloperoxidase in bronchoalveolar lavage were significantly reduced in the study group (81.32 +/- 15.23 vs 53.55 +/- 15.48 pg/mL, 75.00 +/- 9.19 vs 50.00 +/- 7.37 u/mL; p < 0.05, respectively), whereas the interleukin-8 levels were similar between both groups (551.63 +/- 119.34 vs 563.68 +/- 137.14 pg/mL, p > 0.05). Total liquid ventilation with FC-77 (3M, St. Paul, MN) reduces biochemical and histologic lung injury in piglets after cardiopulmonary bypass.
    The Annals of thoracic surgery 08/2006; 82(1):124-30. · 3.74 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

adverse pulmonary sequelae
 
cardiopulmonary bypass
 
characteristic impedance
 
control animals
 
control group
 
flow rate
 
hypothermic bypass
 
infant cardiopulmonary bypass results
 
input pulmonary resistance
 
Liquid ventilation
 
liquid-ventilated group
 
Low-flow cardiopulmonary bypass
 
multiorgan system dysfunction
 
neonatal cardiopulmonary bypass
 
neonatal swine
 
Organ protective strategies
 
prebypass values
 
severe injury
 
significant decrease
 
static pulmonary compliance