Article

In vitro antimycobacterial activity of 5-chloropyrazinamide.

Veterans Affairs Medical Center, Syracuse, New York 13210, USA.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 02/1998; 42(2):462-3.
Source: PubMed

ABSTRACT 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

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