Cadmium toxicity in growing swine.

Journal of Nutrition (Impact Factor: 4.2). 07/1973; 103(7):964-72.
Source: PubMed

ABSTRACT Cadmium (Cd) as cadmium chloride was added to the basal diet of 8-week-old swine at levels of 0, 50, 150, 450 and 1350 ppm for a 6-week comparison period. Growth rate was decreased as a function of Cd level, having ceased in the 1350 ppm group. Hematocrit values were the most sensitive measurement of toxicity and were decreased in all Cd-fed animals. Serum phosphorus was decreased in animals receiving 450 and 1350 ppm Cd, while serum calcium was not affected by Cd intake. Bone ash content was decreased as a function of Cd intake. Leucine aminopeptidase (LAP) activity was depressed in renal cortex from the groups receiving 150 ppm Cd or more, but serum LAP was unaffected by Cd intake. The kidney, liver, spleen and teeth contained the highest concentrations of Cd. Kidney Cd increased with dietary Cd level but appeared to reach a near maximal level in the 450 and 1350 ppm Cd groups. This renal Cd content was directly related to the level of cadmium-binding protein isolated from kidney cortex by gel filtration chromatography. 30 references, 2 figures, 6 tables.

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    ABSTRACT: This study was conducted to investigate the toxicity of cadmium and to evaluate the effectiveness of maifanite in preventing cadmium-induced adverse effects. Thirty-two crossbred pigs (Duroc × Landrace × Large white, sex balanced, 17.25 ± 0.07 kg average body weight) were randomly allotted to one of four dietary treatments in a 2 × 2 factorial arrangement, with eight replicates per treatment and one pig per replicate. The dietary treatments included two cadmium (as CdCl2) doses (0.32 and 30.49 mg/kg) and two maifanite doses (0 and 1 %). The results showed that pigs treated with cadmium decreased their average daily feed intake (P < 0.05) and increased (P < 0.05) the feed/gain ratio. Cadmium was found in the tissues of pigs that were fed with cadmium-contaminated diets, but the level of cadmium was much lower when maifanite was added to the cadmium-contaminated diets. Ingestion of diets that were artificially contaminated with cadmium (30.49 mg/kg of cadmium) reduced (P < 0.05) the number of lymphocytes, the total erythrocyte count, the hemoglobin level, and the hematocrit. However, the activities of serum aspartate aminotransferase and gamma glutamyltransferase were increased (P < 0.05). The total protein level was lower (P < 0.05) in pigs fed with cadmium-contaminated diets. The contents of malondialdehyde increased (P < 0.05), while the total antioxidant capacity and the activities of total superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and catalase decreased (P < 0.05) in pigs fed with cadmium-contaminated diets. Dietary addition of maifanite can, to some extent, prevent the negative effects associated with feeding cadmium diets (30.49 mg/kg of cadmium) to pigs.
    Biological trace element research 08/2013; · 1.92 Impact Factor
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    ABSTRACT: Cadmium injections during molar tooth development in the rat were strongly caries-promoting in female rats. Cadmium also partially negated the cariostatic effect of fluoridated drinking water in both male and female rats. The mechanism for the caries-promoting properties of cadmium is unknown, but may be related to cadmium uptake into enamel and dentin. Cadmium was taken up into molar enamel and dentin in proportion to the amount of cadmium administered, but cadmium did not influence uptake of fluoride onto eruted enamel. Calcium and ash concentrations in molar enamel were not altered by cadmium administration.
    Archives of Environmental Health An International Journal 05/1980; 35(3):176-80.
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    ABSTRACT: Typescript. Thesis--Rutgers University. Vita. Includes bibliographical references (leaves 112-127).


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