Article

What real influence does the proto-oncogene c-myc have in OSCC behavior?

Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.
Oral Oncology (impact factor: 2.86). 06/2011; 47(8):688-92. DOI:10.1016/j.oraloncology.2011.05.016 pp.688-92
Source: PubMed

ABSTRACT The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.

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Keywords

carcinogenic process
 
cell proliferation regulation
 
genetic
 
genetic amplification studies
 
immunohistochemistry
 
molecular interactions
 
OSCC
 
pathological variables