Article

Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum.

Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, Zunyi, China.
Gastroenterology (impact factor: 11.68). 05/2011; 141(3):854-63. DOI:10.1053/j.gastro.2011.05.044
Source: PubMed

ABSTRACT The reason that women have a lower prevalence of duodenal ulcer is not clear. We investigated whether estrogen regulates human duodenal bicarbonate secretion (DBS) and whether this process accounts for sex differences in the prevalence of duodenal ulcer.
We performed an epidemiologic study to correlate duodenal ulcer prevalence with sex and age. Proximal DBS was measured from healthy subjects. Estrogen-receptor expression was examined in human duodenal mucosa by immunoblot and immunohistochemical analyses.
Among women, the prevalence of duodenal ulcer was significantly lower than among men. The reduced prevalence was greatest among premenopausal women (20-49 y), who were 3.91- to 5.09-fold less likely to develop duodenal ulcers than age-matched men; the difference was reduced to 1.32-fold or less among subjects aged 60 years or older. Premenopausal (20-29 y), but not postmenopausal (60-69 y), women had significantly higher basal and acid-stimulated DBS than the age-matched men. Basal and acid-stimulated DBS in premenopausal women (20-29 y) were significantly higher than in postmenopausal women (60-69 y), whereas there were no significant differences in basal or acid-stimulated DBS between men who were aged 20-29 years or 60-69 years. Serum levels of estradiol changed in parallel with basal and acid-stimulated DBS during the physiological menstrual cycle in premenopausal women. 17β-estradiol-stimulated DBS was independent of age or sex. Estrogen receptors α and β were detected on plasma membranes and in the cytosol of human duodenal epithelial cells.
Estrogen regulates human DBS, which could reduce the risk for duodenal ulcer in women and contribute to sex differences in the prevalence of duodenal ulcer.

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Keywords

17β-estradiol-stimulated DBS
 
acid-stimulated DBS
 
age-matched men
 
correlate duodenal ulcer prevalence
 
Estrogen receptors α
 
Estrogen regulates human DBS
 
Estrogen-receptor expression
 
human duodenal epithelial cells
 
human duodenal mucosa
 
immunohistochemical analyses
 
physiological menstrual cycle
 
plasma membranes
 
postmenopausal
 
postmenopausal women
 
Premenopausal
 
premenopausal women
 
process accounts
 
Proximal DBS
 
Serum levels
 
sex differences
 

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