The role of cytopathology in diagnosing HPV induced oropharyngeal lesions
ABSTRACT HPV detection in fine needle aspirates from suspected head and neck metastasis may be useful in clinching the diagnosis of HPV related oral squamous cell carcinoma. Ascertaining the HPV status of a particular tumor on cytological specimens could be useful for prognostication as HPV-related tumors appear to have a better prognosis and clinical outcome. The various techniques of detection are reviewed.
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ABSTRACT: Stage of disease at the diagnosis of oral cancer is thought to be a significant factor in prognosis and outcome (International Agency for Research on Cancer/World Health Organization, 2014). Unfortunately, we continue to diagnose almost 2/3 of these cancers at advanced stages of disease despite the ongoing research for devices/methods to aid the clinicians in detection and accurate oral mucosal lesion diagnosis. This paper explores both the nature of oral cancer and the adjuncts available for detection, and presents the current issues in diagnostic delays of oral cancer detection.Oral Oncology 09/2014; DOI:10.1016/j.oraloncology.2014.09.005 · 3.03 Impact Factor
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ABSTRACT: A significant proportion of squamous cell carcinomas (SCC) of the oropharynx are associated with high-risk human papillomavirus (HPV). These HPV-related carcinomas are prognostically and therapeutically different from traditional SCC of the head and neck. Cervical metastases from head and neck primary SCC are frequently investigated by fine-needle aspiration (FNA). HPV testing of cytologic samples from these lesions would potentially simplify diagnosis and therapeutic planning. This review summarizes current methodologies for HPV testing of FNA specimens and the role of HPV typing in diagnosis, prediction of prognosis, and selection of therapy.Diagnostic Cytopathology 06/2012; 40(6):491-7. DOI:10.1002/dc.22837 · 1.52 Impact Factor
- Oral Cytology A Concise Guide, 1st edited by Ravi Mehrotra, 01/2013: chapter 6: pages 73-90; Springer New York., ISBN: 978-1-4614-5220-1