Vulvar Manifestations of Crohnʼs Disease
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.The American Journal of dermatopathology (Impact Factor: 1.39). 06/2011; 33(6):588-93. DOI: 10.1097/DAD.0b013e31820a2635
Crohn's disease is an inflammatory bowel disorder with several well-known extraintestinal manifestations, such as erythema nodosum, uveitis, and arthritis. Less commonly observed are vulvar manifestations, which have primarily been discussed in case reports or small case series. These cases generally highlight patients with histopathology limited to noncaseating granulomas. As these histological findings are identified in bowel biopsies from only approximately 50% of patients with gastrointestinal Crohn's disease, there is likely an under-recognition and underdiagnosis of vulvar lesions as Crohn's disease manifestations. We describe the largest case series to date involving patients with vulvar Crohn's disease, discuss the varied clinical presentations, and describe the histopathological findings, which include noncaseating granulomas, ulcerations, lymphatic lesions, and even dysplasia and carcinoma. Our findings underscore the importance of keeping vulvar Crohn's disease on the differential diagnosis when faced with a range of vulvar symptoms and suggest that regular gynecological surveillance in patients with Crohn's disease may be of benefit.
- [Show abstract] [Hide abstract]
ABSTRACT: Although Crohn disease (CD) is considered an inflammatory bowel disease, extraintestinal gynecologic manifestations are varied, frequent, and oftentimes difficult to manage. Its predilection for young and reproductive-age women makes it an important disease process for the gynecologist to understand, as its complications can have long-term repercussions on the developmental, sexual, reproductive, and psychological health of affected women. Patients may present with a variety of vulvovaginal, perineal, perianal, and urologic complaints. Perianal involvement from an intestinal fistula is the most common skin manifestation seen in CD. Other gynecologic manifestations include metastatic CD and rectovaginal and urovaginal fistulas. Recognition and accurate diagnosis of extraintestinal gynecologic manifestations, as well as a good understanding of the gynecologic effects of chronic disease, are necessary for optimal management. The article provides an overview of CD and highlights the gynecologic considerations in caring for women affected by this disease. Target Audience: Obstetricians and gynecologists, family physicians Learning Objectives: After completing this CME activity, physicians should be better able to identify the varied gynecologic presentations of Crohn disease, select appropriate diagnostic and imaging modalities, and counsel women regarding the effects of Crohn disease on pregnancy and menarche.Obstetrical & gynecological survey 01/2013; 68(1):51-61. DOI:10.1097/OGX.0b013e31827b1658 · 1.86 Impact Factor
- European journal of obstetrics, gynecology, and reproductive biology 10/2013; 172(1). DOI:10.1016/j.ejogrb.2013.10.020 · 1.70 Impact Factor
- European journal of obstetrics, gynecology, and reproductive biology 11/2013; 172(1). DOI:10.1016/j.ejogrb.2013.10.025 · 1.70 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.