African mango (IGOB131): A proprietary seed extract of Irvingia gabonensis is found to be effective in reducing body weight and improving metabolic parameters in overweight humans

College of Nursing and Health Professions, Drexel University, 1505 Race St., Philadelphia, PA 19102, USA.
Holistic nursing practice (Impact Factor: 0.62). 07/2011; 25(4):215-7. DOI: 10.1097/HNP.0b013e318222735a
Source: PubMed
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    • "I. gabonensis has been hypothesized to possess antidiabetic properties due to its ability to decrease fasting blood sugar levels (Adamson, Okafor, & Abu-Bakare, 1990), and has also been demonstrated to inhibit adipogenesis in vitro (Oben, Ngondi, & Blum, 2008). I. gabonensis also reportedly possesses anticholesterol properties (Tchoundjeu, & Atangana, 2007; Ross, 2011). I. gabonensis has become popular as a weight loss supplement, and has been reported in the media as the new " obesity killer " (, "
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    ABSTRACT: ABSTRACT The aim of this systematic review was to evaluate the evidence from randomized controlled trials (RCTs) involving the use of the African Bush Mango, Irvingia gabonensis for body weight reduction in obese and overweight individuals. Electronic and nonelectronic searches were conducted to identify relevant RCTs. The bibliographies of located articles were also searched. No age, gender, or language restrictions were imposed. The reporting quality of identified RCTs was assessed using a methodological checklist adapted from the Consolidated Standard of Reporting Trials Statement and Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Two reviewers independently determined eligibility and assessed the reporting quality of included studies. Three RCTs were identified, and all were included. The RCTs all had flaws in the reporting of their methodology. All RCTs reported statistically significant reductions in body weight and waist circumference favoring I. gabonensis over placebo. The results from the RCTs also suggest positive effects of I. gabonensis supplementation on the blood lipid profile. Adverse events included headache and sleep difficulty. Due to the paucity and poor reporting quality of the RCTs, the effect of I. gabonensis on body weight and related parameters are unproven. Therefore, I. gabonensis cannot be recommended as a weight loss aid. Future research in this area should be more rigorous and better reported.
    Journal of Dietary Supplements 03/2013; 10(1):29-38. DOI:10.3109/19390211.2012.760508
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    ABSTRACT: Dietary supplements based on an extract from Irvingia gabonensis (African mango, AM) seeds are one of the popular herbal weight loss dietary supplements in the U.S. market. The extract is believed to be a natural and healthy way to lose weight and improve overall health. However, the chemical composition of AM-based dietary supplements (AMDSs) has never been reported. In this study, the chemical constituents of AM seeds, AM seeds extract (AMSE), and different kinds of commercially available AMDSs have been investigated using an ultra high-performance liquid chromatography with high resolution mass spectrometry method. Ellagic acid, mono-, di-, and tri-O-methyl-ellagic acids, and their glycosides were found as major components in AM seeds. These compounds may be used for quality control of AM extract and related dietary supplements.
    Journal of Agricultural and Food Chemistry 08/2012; 60(35):8703-9. DOI:10.1021/jf302703u · 2.91 Impact Factor
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    ABSTRACT: Chronic kidney disease continues to represent a significant health problem in all societies. One of the main factors accelerating renal progression is nephrotoxins. The African mango is a plant added to many foods and commonly consumed in West Africa. No toxic effect has to date been shown. Our aim was to discuss the 42-year-old patient who became dialysis-dependent through developing rapid renal progression following 2.5-month African mango use. To the best of our knowledge, our patient is the first case of chronic renal insufficiency developing in association with African mango consumption.
    International Journal of Clinical and Experimental Medicine 07/2015; 8(4):6374-8. · 1.28 Impact Factor