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The metabolic serine hydrolases and their functions in mammalian physiology and disease

The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Chemical Reviews (Impact Factor: 45.66). 06/2011; 111(10):6022-63. DOI: 10.1021/cr200075y
Source: PubMed

ABSTRACT The largest category of substrates for metabolic SHs is small molecules, which include neutral fatty acyl esters, acyl thioesters phospholipids, lipid amides, and other ester metabolites. The distribution of TGs and recycling of lipoprotein remnants occurs by the action of LPL, LIPC, LCAT, and LIPA. Lumenally oriented LPL and LIPC hydrolyze TGs and cholesteryl esters from chylomicrometer and VLDL particles to generate free fatty acids that can be absorbed and used by tissues. Multiple studies of deficiency in PNLIP have been reported, though none have conclusively demonstrated the extent of the contribution of PNLIP to dietary TG absorption. The available data from both humans and rodents support a role for LIPA in the hydrolysis of cholesteryl esters and TG from internalized LDL particles. While the pancreatic function in these mice is normal, there is an overall decrease in food intake, fat weight, and total weight, and pair feeding studies show that reduced adiposity is due to the reduced caloric intake.

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