Polymer Nanoneedle-Mediated Intracellular Drug Delivery

Biomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA.
Small (Impact Factor: 8.37). 07/2011; 7(14):2094-100. DOI: 10.1002/smll.201100497
Source: PubMed


Delivery of drugs into the cellular cytoplasm of target cells represents a major hurdle in treating various diseases. This challenge can be addressed by encapsulation of drugs onto or within nanoparticles, which can then be targeted to diseased cells. Here, needle-shaped particles are shown to exhibit substantially higher cytoplasmic delivery of drugs such as siRNA compared to their spherical counterparts. Furthermore, these needles are designed to lose their sharp tips over time and can render themselves ineffective over time, thereby offering control over their duration of activity and toxicity. Such polymer nanoneedles open new avenues for delivering drug molecules directly into the cytoplasm with low toxicity.

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    • "Cylindrical-shape PLGA nanoparticles have been used for the delivery of docetaxel to mice bearing a human ovarian carcinoma SKOV-3 flank xenograft (Chu et al., 2013). Needle shaped nanoparticles has been used for the delivery of siRNA in the cytoplasm (Kolhar et al., 2011). A number of specialized techniques were investigated for the design of nanoparticles of varying geometric shapes. "
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    • "Finally, based on the troublesome nature of the fluorescein label, a more quantitative/absolute approach to studying the shape effect on nanoparticle uptake with nanomedical prospects and the efficiency of different particles in cargo delivery could constitute a more correlative approach. To date, this has been successfully measured in the extent of causing cytotoxicity upon delivery of the chemotherapeutic agent camptothecin or paclitaxel [13] or the efficacy of GFP knockdown [39] upon siRNA delivery, and similar approaches will also be pursued in our ongoing and future studies. "
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