Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Journal Article: Journal of psychiatry & neuroscience: JPN (impact factor: 3.58). 07/2011; 37(1):53-7. DOI: 10.1503/jpn.100175
Abstract
We analyzed the association between KMO gene polymorphisms and CSF concentrations of KYNA in patients with schizophrenia and healthy controls. Fifteen single nucleotide polymorphisms (SNPs) were selected covering KMO and were analyzed in UNPHASED.
We included 17 patients with schizophrenia and 33 controls in our study. We found an association between a KMO SNP (rs1053230), encoding an amino acid change of potential importance for substrate interaction, and CSF concentrations of KYNA.
Given the limited sample size, the results are tentative until replication.
Our results suggest that the nonsynonymous KMO SNP rs1053230 influences CSF concentrations of KYNA.
Source: PubMed
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