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Re: Ward K, Ogilvie JW, Singleton MV, et al. Validation of DNA-based prognostic testing to predict spinal curve progression in adolescent idiopathic scoliosis. Spine 2010;35:E1455-64.

Associate Professor, Washington University School of Medicine Department of Orthopaedic Surgery Saint Louis, Missouri (Dobbs) Assistant Professor, Washington University School of MedicineDepartments of Neurology, Pediatrics, and Orthopaedic SurgerySaint Louis, Missouri (Gurnett).
Spine (Impact Factor: 2.45). 07/2011; 36(15):1257; author reply 1257. DOI: 10.1097/BRS.0b013e31821987ba
Source: PubMed
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    ABSTRACT: Study Design. A genetic association study of single nucleotide polymorphisms (SNPs) previously reported to be associated with curve progression of adolescent idiopathic scoliosis (AIS).Objective. To determine whether the association of 53 SNPs with curve progression reported in Caucasian AIS are replicated in Japanese AIS.Summary of Background Data. Predicting curve progression is important in clinical practice of AIS. The progression of AIS is reported to be associated with a number of genes. Associations with 53 SNPs have been reported, and the SNPs are used for a progression test in Caucasian AIS; however, there has been no replication study for their association.Methods. We recruited 2,117 AIS patients with ≧ 10° (Cobb angle) of scoliosis curves. They were divided into progression and non-progression groups according to their Cobb angle. We defined the progression of the curve as Cobb angle > 50° for skeletally mature subjects, > 40° for immature ones, and postoperative ones. We defined the non-progression of the curve as Cobb angle ≦50° only for skeletally mature subjects. 1,714 of 2,117 AIS patients were allocated to either the progression or non-progression group. We evaluated the association of 53 SNPs with curve progression by comparing risk allele frequencies between the two groups.Results. We evaluated the progression (N = 600) and non-progression (N = 1,114) subjects, and their risk allele frequencies were not different significantly. We found no replication of the association on AIS curve progression in any of the SNPs.Conclusion. The associations of the 53 SNPs with progression of AIS curve are not definite. Large-scale association studies based on appropriate criteria for progression would be necessary to identify SNPs associated with the curve progression.
    Spine 04/2013; 38(16). DOI:10.1097/BRS.0b013e3182947d21 · 2.45 Impact Factor