Task-Specific Modulation of Human Auditory Evoked Response in a Delayed-Match-To-Sample Task

Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health Bethesda, MD, USA.
Frontiers in Psychology (Impact Factor: 2.8). 05/2011; 2:85. DOI: 10.3389/fpsyg.2011.00085
Source: PubMed


In this study, we focus our investigation on task-specific cognitive modulation of early cortical auditory processing in human cerebral cortex. During the experiments, we acquired whole-head magnetoencephalography data while participants were performing an auditory delayed-match-to-sample (DMS) task and associated control tasks. Using a spatial filtering beamformer technique to simultaneously estimate multiple source activities inside the human brain, we observed a significant DMS-specific suppression of the auditory evoked response to the second stimulus in a sound pair, with the center of the effect being located in the vicinity of the left auditory cortex. For the right auditory cortex, a non-invariant suppression effect was observed in both DMS and control tasks. Furthermore, analysis of coherence revealed a beta band (12∼20 Hz) DMS-specific enhanced functional interaction between the sources in left auditory cortex and those in left inferior frontal gyrus, which has been shown to be involved in short-term memory processing during the delay period of DMS task. Our findings support the view that early evoked cortical responses to incoming acoustic stimuli can be modulated by task-specific cognitive functions by means of frontal-temporal functional interactions.

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Available from: Fatima T Husain, Oct 01, 2015
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    • "This is important, given that network analysis techniques, especially graph theory, are commonly employed in MRI studies of structural and functional connectivity (Achard et al., 2006; Bassett and Bullmore, 2006; Bullmore and Sporns, 2009; Sporns, 2012), and as we shall see, these network metrics can be utilized for investigating brain disorders. Finally, even though the current paper is focused on fMRI functional/effective connectivity, it is worth noting that there also is a vast literature in which brain connectivity analyses are performed on EEG/MEG data (e.g., Gevins and Bressler, 1988; Gross et al., 2001; Daunizeau et al., 2009; Brookes et al., 2011; Rong et al., 2011), and large-scale neural modeling has been employed to help interpret experimental findings (for example, see Wendling et al., 2009; Banerjee et al., 2012). "
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    ABSTRACT: Recently, there have been a large number of studies using resting state fMRI to characterize abnormal brain connectivity in patients with a variety of neurological, psychiatric, and developmental disorders. However, interpreting what the differences in resting state fMRI functional connectivity (rsfMRI-FC) actually reflect in terms of the underlying neural pathology has proved to be elusive because of the complexity of brain anatomical connectivity. The same is the case for task-based fMRI studies. In the last few years, several groups have used large-scale neural modeling to help provide some insight into the relationship between brain anatomical connectivity and the corresponding patterns of fMRI-FC. In this paper we review several efforts at using large-scale neural modeling to investigate the relationship between structural connectivity and functional/effective connectivity to determine how alterations in structural connectivity are manifested in altered patterns of functional/effective connectivity. Because the alterations made in the anatomical connectivity between specific brain regions in the model are known in detail, one can use the results of these simulations to determine the corresponding alterations in rsfMRI-FC. Many of these simulation studies found that structural connectivity changes do not necessarily result in matching changes in functional/effective connectivity in the areas of structural modification. Often, it was observed that increases in functional/effective connectivity in the altered brain did not necessarily correspond to increases in the strength of the anatomical connection weights. Note that increases in rsfMRI-FC in patients have been interpreted in some cases as resulting from neural plasticity. These results suggest that this interpretation can be mistaken. The relevance of these simulation findings to the use of functional/effective fMRI connectivity as biomarkers for brain disorders is also discussed.
    Frontiers in Human Neuroscience 11/2013; 7:649. DOI:10.3389/fnhum.2013.00649 · 2.99 Impact Factor
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    • "In addition, they found a correlation of activity with the task performance in the SMG in both hemispheres but this correlation was stronger on the left side (Gaab et al., 2003). Furthermore, a magnetoencephalography (MEG) study also revealed a task-specific asymmetry in activity during an auditory delayed match-to-sample task (Rong et al., 2011). They found a left-lateralized suppression effect to the second stimulus in a sound pair of tonal contours during the performance of this task, compared with passive listening and counting. "
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    ABSTRACT: Evaluating series of complex sounds like those in speech and music requires sequential comparisons to extract task-relevant relations between subsequent sounds. With the present functional magnetic resonance imaging (fMRI) study, we investigated whether sequential comparison of a specific acoustic feature within pairs of tones leads to a change in lateralized processing in the auditory cortex (AC) of humans. For this we used the active categorization of the direction (up vs. down) of slow frequency modulated (FM) tones. Several studies suggest that this task is mainly processed in the right AC. These studies, however, tested only the categorization of the FM direction of each individual tone. In the present study we ask the question whether the right lateralized processing changes when, in addition, the FM direction is compared within pairs of successive tones. For this we use an experimental approach involving contralateral noise presentation in order to explore the contributions made by the left and right AC in the completion of the auditory task. This method has already been applied to confirm the right-lateralized processing of the FM direction of individual tones. In the present study, the subjects were required to perform, in addition, a sequential comparison of the FM direction in pairs of tones. The results suggest a division of labor between the two hemispheres such that the FM direction of each individual tone is mainly processed in the right AC whereas the sequential comparison of this feature between tones in a pair is probably performed in the left AC.
    Frontiers in Neuroscience 07/2013; 7(7):115. DOI:10.3389/fnins.2013.00115 · 3.66 Impact Factor
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    ABSTRACT: Temporal pole (TP) cortex is associated with higher-order sensory perception and/or recognition memory as human patients with damage in this region show impaired performance during some tasks requiring recognition memory (Olson et al., 2007). The underlying mechanisms of TP processing are largely based on examination of the visual nervous system in humans and monkeys, while little is known about neuronal activity patterns in the auditory portion of this region, dorsal temporal pole (dTP; Poremba et al., 2003). The present study examines single-unit activity of dTP in rhesus monkeys performing a delayed matching-to-sample (DMS) task utilizing auditory stimuli, wherein two sounds are determined to be the same or different. Neurons of dTP encode several task-relevant events during the DMS task, and encoding of auditory cues in this region is associated with accurate recognition performance. Population activity in dTP shows a match suppression mechanism to identical, repeated, sound stimuli similar to that observed in the visual object identification pathway located ventral to dTP (Desimone, 1996; Nakamura and Kubota, 1996). However, in contrast to sustained visual delay-related activity in nearby analogous regions, auditory delay-related activity in dTP is transient and limited. Neurons in dTP respond selectively to different sound stimuli, and often change their sound response preferences between experimental contexts. Current findings suggest a significant role for dTP in auditory recognition memory similar in many respects to the visual nervous system; while delay memory firing patterns are not prominent which may relate to monkeys' shorter forgetting thresholds for auditory versus visual objects.
    Journal of Neurophysiology 11/2013; 111(3). DOI:10.1152/jn.00401.2012 · 2.89 Impact Factor
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