Article

Important role of oxidative stress biomarkers in Huntington's disease.

Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Universidad de Córdoba, Córdoba, Spain.
Journal of Medicinal Chemistry (impact factor: 4.8). 06/2011; 54(15):5602-6. DOI:10.1021/jm200605a pp.5602-6
Source: PubMed

ABSTRACT This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

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Keywords

19 patients
 
antioxidant system
 
antioxidant systems
 
carbonylated proteins
 
global oxidative stress
 
oxidative stress
 
oxidative stress biomarkers
 
pathogenesis
 

Isaac Túnez