Interventions for primary vesicoureteric reflux

Renal Division, Department of Internal Medicine, University Hospital Ghent, Ghent, Belgium.
Cochrane database of systematic reviews (Online) (Impact Factor: 6.03). 06/2011; DOI: 10.1002/14651858.CD001532.pub4
Source: PubMed


Vesicoureteric reflux (VUR) is the backflow of urine from the bladder up the ureters to the kidney. People with VUR are thought to be more likely to get urinary tract infections (UTIs) involving the kidney tissue, which may cause permanent kidney damage. Current treatment options include reimplantation of the ureters or endoscopic surgery, long-term antibiotics, endoscopic correction (injection of a substance around the entry of the ureter into the bladder) using different materials, or a combination of interventions. This review found no strong evidence that long-term antibiotic prophylaxis prevented repeat UTIs in children with VUR. Associated side effects were infrequent and minor, but prophylaxis was associated with a threefold increased risk of bacterial resistance to the treatment drug in subsequent infections. Surgery decreased the number of UTIs with fever, but did not change the number of children developing symptomatic UTI or kidney damage.

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Available from: Elisabeth M Hodson, Aug 18, 2014
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