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[Acridines as antitumor drugs].

Anita Dopierała, Patrycja Wrosz, Jan Mazerski

Katedra Technologii Leków i Biochemii, Wydział Chemiczny, Politechnika Gdańska.

Journal Article: Postępy Higieny i Medycyny Doświadczalnej (Advances in Hygiene and Experimental Medicine) 01/2011; 65:263-9.

Abstract

Acridines belong to a group of polycyclic heteroaromatic compounds and exhibit a broad spectrum of biological activity including antiprotozoal, antibacterial, antiviral and antitumor activity. Acridine derivatives with antitumor activity have different mechanisms of action at the molecular level. The data obtained so far indicate that one of the main steps is the formation of physico-chemical complexes with DNA. Among acridine derivatives with anticancer activity we can distinguish five main classes of compounds: nitroacridines, 9-anilinoacridines, pyrazoloacridines, imidazoacridines, and triazoloacridines. Compounds from different classes differ both in mechanism of action and spectrum of antitumor activity.

Source: PubMed

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Keywords

9-anilinoacridines
 
Acridine derivatives
 
Acridines
 
antiprotozoal
 
antitumor activity
 
broad spectrum
 
compounds
 
different classes
 
imidazoacridines
 
main steps
 
molecular level
 
nitroacridines
 
physico-chemical complexes
 
polycyclic heteroaromatic compounds
 
pyrazoloacridines
 
triazoloacridines