Article

The 981C>T polymorphism in protein tyrosine phosphatase 1B is associated with decreased risk of coronary artery disease in Chinese Han population.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.
Atherosclerosis (impact factor: 3.79). 05/2011; 218(1):147-50. DOI:10.1016/j.atherosclerosis.2011.05.021 pp.147-50
Source: PubMed

ABSTRACT The present study was designed to investigate the potential association between the 981C>T polymorphism in protein tyrosine phosphatase 1B (PTP-1B) and coronary artery disease (CAD).
We conducted a hospital-based case-control study with 864 CAD patients and 1008 controls to explore the association between the PTP-1B 981C>T polymorphism and risk of CAD in Chinese Han population.
Subjects with the variant genotypes (CT+TT) had a 52% decreased risk of CAD relative to CC carriers (adjusted odds ratio, 0.48; 95% confidence interval, 0.39-0.60). The 981C>T polymorphism was associated with a higher body mass index and serum triglyceride levels in both CAD patients and controls. Moreover, this polymorphism was found to be associated with a lower serum glucose levels in cases, but not in controls.
Our study demonstrates that the PTP-1B 981C>T polymorphism is associated with decreased risk of CAD in Chinese Han population.

0 0
 · 
0 Bookmarks
 · 
40 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

864 CAD patients
 
95% confidence interval
 
981C>T polymorphism
 
CAD
 
CAD patients
 
cases
 
CC carriers
 
Chinese Han population
 
coronary artery disease
 
higher body mass index
 
hospital-based case-control study
 
odds ratio
 
protein tyrosine phosphatase 1B
 
PTP-1B
 
PTP-1B 981C>T polymorphism
 
serum triglyceride levels
 

Xiang Zhou