Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea

School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Marine Drugs (Impact Factor: 2.85). 12/2011; 9(5):832-43. DOI: 10.3390/md9050832
Source: PubMed

ABSTRACT Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC₅₀ values ranging from 13.1 to 29.1 μM.

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    • "Compound one was evaluated for in vitro cytotoxic activity against two human cancer cell lines including human breast MCF-7 and human Liver HepG2 by MTT assay[1617] using epirubicin (an anticancer drug used widely in the clinic[1819]) as positive control. The results are summarized in Table 2. Compound one was moderately active against MCF-7 and HepG2 cells as compared with the standard. "
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