Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts

Department of Orthopaedics, The Sixth People's Hospital Affiliated, Shanghai Jiao Tong University, China.
The Brazilian journal of infectious diseases: an official publication of the Brazilian Society of Infectious Diseases (Impact Factor: 1.3). 06/2011; 15(3):189-94. DOI: 10.1016/S1413-8670(11)70173-8
Source: PubMed


Activation of nuclear factor kappaB by diverse bacteria regulates the secretion of chemokines and cytokines. Staphylococcus aureus (S. aureus)-infected osteoblasts can significantly increase the secretion of interleukin-6 and monocyte chemoattractant protein-1. The aim of this study was to investigate whether S. aureus can activate nuclear factor kappaB in human osteoblasts, and whether the activation of nuclear factor kappaB by S. aureus regulates the secretion of interleukin-6 and monocyte chemoattractant protein-1.

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    • "In the present study, in accordance with the current knowledge on osteoblasts responses to S. aureus, we found that infection with the strain Sa49230 elicited the secretion of IL-6 from MG-63 cells (Ning et al. 2011). This secretion seemed to be strain dependent, since stimulation of osteoblasts with the other S. aureus elicited a lower IL-6 response and did not result in IL- 6 secretion. "
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    • "All the manifestations were provoked by the severity and the duration of the staphylococcal infection posing thereafter a question whether this immunologic abnormality was triggered by specific staphylococcal antigens or by the chronic inflammation. Several works have demonstrated that Staphylococcus aureus infected osteoblasts in osteomyelitis induce IL-6 and IL-12 secretion [13]. IL-6 acts a growth factor for B-cell differentiation and terminal maturation into antibody producing plasma cells [14]. "
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