Article

Bilateral Giant Juvenile Fibroadenomas of Breasts:A Case Report

Department of Pathology, Krishna Institute of Medical Sciences, Karad, District Satara, Maharashtra 415110, India.
Pathology research international 05/2011; 2011:482046. DOI: 10.4061/2011/482046
Source: PubMed

ABSTRACT Juvenile fibroadenoma constitutes only 4% of the total fibroadenomas. The incidence of giant juvenile fibroadenomas is found to be only 0.5% of all the fibroadenomas. Bilateral giant juvenile fibroadenomas are extremely rare, and only four cases have been reported in the literature. To the best of our knowledge, we are presenting the fifth case of bilateral giant juvenile fibroadenomas in a 12-year-old prepubertal girl. The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology. In this paper, we present this rare case to illustrate the diagnosis and management of this tumour and to emphasize that these tumours are almost always benign and should be treated with breast-conserving surgery to provide a healthy physical and social life to the patient.

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    • "Peak incidence occurs in late adolescence, age 10 to 18 years, with African-American females at increased risk4,5). However, some giant fibroadenomas have been reported in Asia and recently in Korea6,7,8). The size of a giant juvenile fibroadenoma is usually more than 5 cm or more than 500 g. "
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    ABSTRACT: A girl (age, 12 years 11 months) consulted the pediatric endocrinology clinic because of a rapidly growing right breast mass over 13 cm observed during the preceding 3 months. A surgical excision was performed, and the mass was diagnosed as a giant juvenile fibroadenoma. Giant juvenile fibroadenomas are rare, usually occurring between 10 and 18 years of age, and characterized by massive and rapid enlargement of an encapsulated mass. The etiology is believed to be an end-organ hypersensitivity to normal levels of estrogen. We report a case of giant juvenile fibroadenoma and present a review of the diagnostic workup and management of a large breast tumor during adolescence.
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