Article

[A new target in non-small cell lung cancer: EML4-ALK fusion gene].

Department of Medical, Henan Tumor Hospital, Zhengzhou 450003, China.
Zhongguo fei ai za zhi = Chinese journal of lung cancer 06/2011; 14(6):538-42. DOI:10.3779/j.issn.1009-3419.2011.06.11 pp.538-42
Source: PubMed

ABSTRACT It was only 3 years ago that the fusion gene between echinoderm microtubule-associated protein-like4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small cell lung cancer (NSCLC). EML4-ALK is most often detected in never smokers with lung adenocarcinoma and has unique pathologic features. EML4-ALK fusion gene is oncogenic, which could be suppressed by ALK-inhibitor through blocking the downstream signaling passway of EML4-ALK. This review will focus on the molecular structure, function, biology, detection method and the diagnostic and therapeutic meaning of EML4-ALK of lung cancer.

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Keywords

ALK-inhibitor
 
anaplastic lymphoma kinase
 
downstream signaling passway
 
echinoderm microtubule-associated protein-like4
 
EML4
 
EML4-ALK
 
EML4-ALK fusion gene
 
fusion gene
 
lung adenocarcinoma
 
non-small cell lung cancer
 
NSCLC
 
therapeutic meaning
 

Huijuan Wang