Role of Lifestyle Changes in the Management of Chronic Liver Disease

Metabolic and Autoimmunity Liver Unit, Bambino Gesù Children's Hospital and Research Institute, S, Onofrio Square, 4, 00165 Rome, Italy.
BMC Medicine (Impact Factor: 7.25). 06/2011; 9(1):70. DOI: 10.1186/1741-7015-9-70
Source: PubMed


The prevalence of obesity worldwide has dramatically increased during the last three decades. With obesity comes a variety of adverse health outcomes which are grouped under the umbrella of metabolic syndrome. The liver in particular seems to be significantly impacted by fat deposition in the presence of obesity. In this article we discuss several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status. The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity. Here we summarize the current evidence supporting non-pharmacological, lifestyle interventions that lead to weight reduction, improved physical activity and better nutrition as part of the management and treatment of these liver conditions.

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Available from: Valerio Nobili, Jul 29, 2014
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    • "Liver disorders are among the most serious sicknesses in the population. Together with healthy lifestyle recommendation, therapies for hepatic diseases are necessary and need be more effective and economical [80]. Botanical medicines have been used traditionally worldwide for the prevention and treatment of liver disease. "
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    ABSTRACT: Ginseng, an ancient and famous medicinal herb in the Orient, has been used as a valuable tonic and for the treatment of various diseases including hepatic disorders. Ginseng saponins, commonly known as ginsenosides, are principal constituents and have believed to be responsible for multiple ginseng health benefits. There are more 40 ginsenosides isolated from ginseng. To date, treatment options for common liver diseases such as cirrhosis, fatty liver, and chronic hepatitis remain problematic. In this regard, ginseng extracts and individual ginsenosides have shown a wide array of beneficial role in the regulation of regular liver functions and the treatment of liver disorders of acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis, hepatocellular carcinoma, and so on in various pathways and mechanisms. In this paper, we first outline the pharmacological effects of ginseng and ginsenosides on the liver functions.
    Evidence-based Complementary and Alternative Medicine 09/2012; 2012(15):173297. DOI:10.1155/2012/173297 · 1.88 Impact Factor
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    • "Regular aerobic exercise has been suggested as an appropriate means for the activation of antioxidant and immunological defenses, reduction of inflammatory processes, and improvement in quality of life, mainly in metabolic syndrome diseases (Kuo et al. 2007; Kelley et al. 2011). Also, the exercise combined with healthy eating, including low fat intake, is highly efficacious for improving serum lipid profiles, quality-of-life , and complications of obesity, metabolic syndrome, and NASH (Zivkovic et al. 2007; Nobili et al. 2011). In chemically induced rodent carcinogenesis models, moderate exercise (running and swimming) reduces the development of preneoplastic and neoplastic lesions in the colon and mammary gland (Hoffman-Goetz 2003; Na and Oliynyk 2011). "
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    ABSTRACT: The present study aimed to investigate the beneficial effects of swim training on the promotion-progression stages of rat liver carcinogenesis. Male Wistar rats were submitted to chemically induced liver carcinogenesis and allocated into 4 major groups, according their dietary regimen (16 weeks) and swim training of 5 days per week (8 weeks): 2 groups were fed low-fat diet (LFD, 6% fat) and trained or not trained and 2 groups were fed high-fat diet (HFD, 21% fat) and trained or not trained. At week 20, the animals were killed and liver samples were processed for histological analyses; immunohistochemical detection of persistent or remodeling preneoplastic lesions (pPNL and rPNL) expressing placental glutathione S-transferase (GST-P) enzyme; or proliferating cell nuclear antigen (PCNA), cleaved caspase-3, and bcl-2 protein levels by Western blotting or malonaldehyde (MDA) and total glutathione detection by HPLC. Overall analysis indicated that swim training reduced the body weight and body fat in both LFD and HFD groups, normalized total cholesterol levels in the HFD group while decreased the MDA levels, increased glutathione levels and both number of GST-P-positive pPNL and hepatocellular adenomas in LFD group. Also, a favorable balance in PCNA, cleaved caspase-3, and bcl-2 levels was detected in the liver from the LFD-trained group in relation to LFD-untrained group. The findings of this study indicate that the swim training protocol as a result of exercise postconditioning may attenuate liver carcinogenesis under an adequate dietary regimen with lowered fat intake.
    Applied Physiology Nutrition and Metabolism 09/2012; 37(6). DOI:10.1139/h2012-129 · 2.34 Impact Factor
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    • "Obesity and the associated metabolic complications are increasingly recognized as independent risk factors for diminished response to therapy and more severe liver disease [14]. Several types of hepatic conditions such as non-alcoholic fatty liver disease and chronic infection with hepatitis C virus are worsened by the presence of obesity in patients [15] [16]. "

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