Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4.
Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500 049, India.Chemical Communications (Impact Factor: 6.38). 07/2011; 47(27):7779-81. DOI:10.1039/c1cc12321a
ABSTRACT A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.
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