This paper presents seven fatal cases of aconite poisoning encountered in the Tongji Center for Medicolegal Expertise in Hubei (TCMEH), China, from 1999 to 2008 retrospectively. In six of the cases, deaths occurred after drinking homemade medicated liquor containing aconite, and in one case death was due to ingestion of traditional Chinese medication containing aconite. Forensic autopsy and pathological examinations ruled out the presence of physical trauma or life-threatening diseases. Diagnosis of aconite poisoning was made after postmortem toxicological analysis. Animal experiment was performed in one case demonstrating that the medicated liquor could cause death rapidly. We present the autopsy and histopathological findings, toxicological analysis, and results of animal experiment done on samples from those seven cases. As an important herbal Chinese medicine, Aconitum species deserve special attention, especially because it contains poisonous alkaloids.
"These medicinal plants constitute important ingredients in some commonly used herbal preparations like Sini Tang, Fuzi Lizhong Wan, and Guifu Dihuang Wan for stroke and heart failure, diarrhea and diabetes, respectively (Chinese Pharmacopoeia Commission, 2010). Poisoning due to homemade medicated liquor containing aconite and traditional medicine containing A. carmichaeli were reported in China between 1999 and 2008 (Liu et al., 2011). Severe cases of cardiac toxicity from consumption of aconitine-containing herbal preparation manifesting as ventricular tachycardia and fibrillation and eventually leading to death have been reported (Tai et al., 1992; Fujita et al., 2007; Dhesi et al., 2010; Lin et al., 2011). "
[Show abstract][Hide abstract] ABSTRACT: The use of herbal medicinal products and supplements has increased tremendously over the past three decades with not less than 80% of people worldwide relying on them for some part of primary healthcare. Although therapies involving these agents have shown promising potential with the efficacy of a good number of herbal products clearly established, many of them remain untested and their use are either poorly monitored or not even monitored at all. The consequence of this is an inadequate knowledge of their mode of action, potential adverse reactions, contraindications, and interactions with existing orthodox pharmaceuticals and functional foods to promote both safe and rational use of these agents. Since safety continues to be a major issue with the use of herbal remedies, it becomes imperative, therefore, that relevant regulatory authorities put in place appropriate measures to protect public health by ensuring that all herbal medicines are safe and of suitable quality. This review discusses toxicity-related issues and major safety concerns arising from the use of herbal medicinal products and also highlights some important challenges associated with effective monitoring of their safety.
Frontiers in Pharmacology 01/2014; 4:177. DOI:10.3389/fphar.2013.00177 · 3.80 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Although proprietary medicines and decoction of processed aconite roots are the most widely used, tincture accounts for the great majority of aconite poisoning cases in China, indicating that it is much more toxic than other formulations. Aconite tincture is often self-prepared at home and raw aconite plants or roots are often used. Even if processed aconite roots were used to make the tincture, the amount of Aconitum alkaloids is highly variable, depending on the adequacy of processing and quality control. Aconitum alkaloids dissolve efficiently in alcohol. For these reasons, tincture contains very high concentrations of Aconitum alkaloids. Despite its high intrinsic toxicity, overdose of aconite tincture by the users has been common. Severe aconite poisoning can be complicated by fatal ventricular tachyarrhythmias and asystole. The public should be repeatedly warned of the danger of taking aconite tincture by mouth.
Forensic science international 03/2012; 222(1-3):1-3. DOI:10.1016/j.forsciint.2012.02.026 · 2.14 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Eponyms are used almost daily in the clinical practice of dermatology. And yet, information about the person behind the eponyms is difficult
to find. Indeed, who is? What is this person’s nationality? Is this person alive or dead? How can one find the paper in which this person first
described the disease? Eponyms are used to describe not only disease, but also clinical signs, surgical procedures, staining techniques,
pharmacological formulations, and even pieces of equipment. In this article we present supplement to eponyms (the letter A to F). The
symptoms and their synonyms, and those who have described this symptom or phenomenon.
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