Article

β-Galactosidase-instructed formation of molecular nanofibers and a hydrogel.

Department of Chemistry, Brandeis University, Waltham, MA 02454, USA.
Nanoscale (Impact Factor: 6.74). 06/2011; 3(7):2859-61. DOI: 10.1039/c1nr10333d
Source: PubMed

ABSTRACT Here we report the first example of using β-galactosidase to trigger the formation of cell compatible, supramolecular nanofibers, which ultimately may lead to a new approach for the development of soft nanotechnology.

0 Followers
 · 
107 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: An L-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, contrasting to the properties of monomeric L-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.
    Organic & Biomolecular Chemistry 07/2014; 12(35). DOI:10.1039/C4OB01362J · 3.49 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hydrogels are a class of special materials that contain a large amount of water and behave like rubber. These materials have found broad applications in tissue engineering, cell culturing, regenerative medicine etc. Recently, the exploration of peptide-based supramolecular hydrogels has greatly expanded the repertoire of hydrogels suitable for biomedical applications. However, the mechanical properties of peptide-based hydrogels are intrinsically weak. Therefore, it is crucial to develop methods that can improve the mechanical stability of such peptide-based hydrogels. In this review, we explore the factors that determine or influence the mechanical stability of peptide-based hydrogels and summarize several key elements that may guide scientists to achieve mechanically improved hydrogels. In addition, we exemplified several methods that have been successfully developed to prepare hydrogels with enhanced mechanical stability. These mechanically strong peptide-based hydrogels may find broad applications as novel biomaterials. It is still challenging to engineer hydrogels in order to mimic the mechanical properties of biological tissues. More hydrogel materials with optimal mechanical properties suitable for various types of biological applications will be available in the near future.
    Science China: Physics, Mechanics and Astronomy 04/2014; 57(5). DOI:10.1007/s11433-014-5427-z · 0.86 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this Perspective, we will discuss how the rate of formation of supramolecular materials can be drastically enhanced by catalytically controlling the rate of formation of their molecular building blocks, resulting in the formation of out-of-equilibrium soft materials with enhanced mechanical properties. Also, the use of surface confined, patterned catalysts allows spatial control over self-assembly, which can be applied to the formation of regular, micrometer sized hydrogel patterns. Catalysis has been applied for decades as an indispensable tool in the synthesis of both simple and highly complex molecules and polymers, ranging from milligram lab-scale to multi-ton industrial processes. However, despite being widespread in nature, until recently the use of catalysis to control the formation of supramolecular materials has remained limited. We will demonstrate the large potential of using catalysis as a tool in the construction of soft materials, illustrated by recent developments.
    Organic & Biomolecular Chemistry 07/2014; 12(33). DOI:10.1039/c4ob01108b · 3.49 Impact Factor

Full-text (2 Sources)

Download
77 Downloads
Available from
Jun 1, 2014