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Paneth cell function--implications in pediatric Crohn disease.

Julia Beisner, Eduard F Stange, Jan Wehkamp

Dr. Margarete Fischer-Bosch, Institute of Clinical Pharmacology and University of Tübingen, Tübingen, Germany.

Journal Article: Gut Microbes 01/2010; 2(1):47-51. DOI: 10.4161/gmic.2.1.14649

Abstract

Defects in the intestinal barrier play a central role in disease pathogenesis. Recently we have demonstrated that children with ileal Crohn's disease show a reduced expression of small intestinal HD-5 at the age of onset suggesting that a compromised mucosal barrier function might be a key factor in the early disease pathogenesis. We also identified a disturbance of the Wnt signaling transcription factor TCF-4 as a major mechanism for this deficiency in children which might result in a compromised innate immune function of small intestinal Paneth cells via defensin secretion. Here we provide a summary on our recent findings and discuss the data in more detail especially focusing on the role of Paneth cell differentiation and function in the pathogenesis of pediatric ileal Crohn's disease.

Source: PubMed

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Keywords

central role
 
children
 
compromised innate immune function
 
compromised mucosal barrier function
 
defensin secretion
 
disease pathogenesis
 
ileal Crohn's disease
 
key factor
 
major mechanism
 
Paneth cell differentiation
 
pathogenesis
 
pediatric ileal Crohn's disease
 
recent findings
 
small intestinal Paneth cells
 
Wnt signaling transcription factor TCF-4