Astrocytoma in an African Hedgehog (Atelerix albiventris) Suspected Wobbly Hedgehog Syndrome
Miwa Exotic Animal Hospital, Tokyo, Japan.Journal of Veterinary Medical Science (Impact Factor: 0.78). 05/2011; 73(10):1333-5. DOI: 10.1292/jvms.10-0341
A 28-month-old African hedgehog was referred to our hospital with progressive tetraparesis. On the first presentation, the hedgehog was suspected as having wobbly hedgehog syndrome (WHS) and the animal was treated with medication and rehabilitation. The animal died 22 days after onset. Pathological examination revealed that the animal was involved in astrocytoma between the medulla oblongata and the spinal cord (C1). This report indicates that a primary central nervous system tumor should be considered as one of the differential diagnoses for hedgehogs presenting with progressive paresis, together with WHS.
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ABSTRACT: A 3-year-old female African hedgehog (Atelerix albiventris) was presented with a progressive history of depression, hyporexia, weight loss, and severe ataxia of the pelvic limbs. The diagnostic blood test results were nonspecific and whole-body radiographs revealed an enlarged spleen. Ultrasonographic images showed splenomegaly with multiple hypoechoic nodules. Based on imaging, an initial diagnosis of a degenerative, vascular, or neoplastic disease was made. Because of a poor prognosis, the owners requested euthanasia and allowed for a pathologic examination of the hedgehog. Histopathologic review of the tissues confirmed that the animal had lymphoma. Lesions were multicentric and involved the spleen, mediastinal lymph node, and central nervous system. To the authors' knowledge, this is the first report of splenic lymphoma with cerebellar involvement in an African hedgehog.Journal of Exotic Pet Medicine 07/2012; 21(3):255–259. DOI:10.1053/j.jepm.2012.06.020 · 0.51 Impact Factor
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ABSTRACT: This report describes an oligoastrocytoma in the brain of a 3.5-year-old female pet African hedgehog (Atelerix albiventris) that showed progressive central nervous system signs for 6 months. Microscopical examination of the brain revealed a widely infiltrative, deep-seated glioma within the white matter of the cerebral hemispheres, basal nuclei, hippocampus, thalamus, midbrain, pons and the medulla of the cerebellum with extension of neoplastic cells into the cerebral cortex and overlying leptomeninges. Morphological features of the neoplastic cells, together with variable immunohistochemical expression of glial fibrillary acidic protein, Olig-2 and Nogo-A, indicated the presence of intermingled astrocytic and oligodendroglial tumour cells with an astrocytic component of approximately 40% consistent with an oligoastrocytoma. The distribution of the tumour is consistent with gliomatosis cerebri.Journal of Comparative Pathology 11/2014; 151(4). DOI:10.1016/j.jcpa.2014.07.002 · 1.14 Impact Factor
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