Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy.

Yixuan Zhang, Stefan P Janssens, Kirstin Wingler, Harald H H W Schmidt, An L Moens

Department of Cardiology, Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.

Journal Article: AJP Heart and Circulatory Physiology (impact factor: 3.71). 05/2011; 301(3):H634-46. DOI: 10.1152/ajpheart.01315.2010

Abstract

The pathogenesis of many cardiovascular diseases is associated with reduced nitric oxide (NO) bioavailability and/or increased endothelial NO synthase (eNOS)-dependent superoxide formation. These findings support that restoring and conserving adequate NO signaling in the heart and blood vessels is a promising therapeutic intervention. In particular, modulating eNOS, e.g., through increasing the bioavailability of its substrate and cofactors, enhancing its transcription, and interfering with other modulators of eNOS pathway, such as netrin-1, has a high potential for effective treatments of cardiovascular diseases. This review provides an overview of the possibilities for modulating eNOS and how this may be translated to the clinic in addition to describing the genetic models used to study eNOS modulation.

Source: PubMed

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Keywords

blood vessels
 
cardiovascular diseases
 
conserving adequate
 
eNOS pathway
 
eNOS)-dependent superoxide formation
 
findings support
 
genetic models
 
modulating eNOS
 
promising therapeutic intervention
 
signaling
 
study eNOS modulation
 
substrate
 
synthase