Article

[Effects of carteolol hydrochloride on experimental choroidal neovascularization].

Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Nippon Ganka Gakkai zasshi 04/2011; 115(4):355-61. pp.355-61
Source: PubMed

ABSTRACT To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV).
Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay.
Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha.
Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.

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Keywords

anti-inflammatory action
 
choroidal neovascularization
 
CNV
 
CNV development
 
enzyme-linked immunosorbent assay
 
fluorescein isothiocyanate-isolectin B 4 staining
 
ICAM-1
 
induce CNV
 
intercellular adhesion molecule
 
monocyte chemotactic protein
 
RAW 264.7 macrophage culture
 
retinal pigment epithelium
 
RPE)-choroid complex
 
significant suppression
 
TNF-alpha
 
tumor necrosis factor
 

Susumu Ishida